Results 71 to 80 of about 4,287,179 (359)

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner, Barwell J, Bruck Taddese, Christopher A. Reynolds, Conner AC, David R. Poyner, Debbie L. Hay, Harriet A. Watkins, James Barwell, Kevin J. Smith, Michael. J. Woolley, Urano D, Watkins HA, Z. Gamze Karakullukcu   +13 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

Frontiers in Endocrinology, 2012
The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid ...
Jean-Luc eDo-Rego, Jae Young eSeong, Delphine eBurel, Jérôme eLEPRINCE, David eVaudry, David eVaudry, Van eLuu-The, Marie-Christine eTonon, Marie-Christine eTonon, Kazuyoshi eTsutsui, Georges ePelletier, Hubert eVaudry, Hubert eVaudry   +12 more
doaj   +1 more source

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Frontiers in Immunology, 2023
Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ...
Georgia F. Papadaki, Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Tyler J. Florio, Michael C. Young, Michael C. Young, Julia N. Danon, Julia N. Danon, Yi Sun, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis, Nikolaos G. Sgourakis   +13 more
doaj   +1 more source

Intracellular interferons in fish : a unique means to combat viral infection [PDF]

, 2013
Peer reviewedPublisher ...
A Lopez-Munoz, A Matsuo, A Pindel, AJ Sadler, B Sun, Bei Huang, Bertrand Collet, C Stein, Chris J. Secombes, CM Ahmed, D Aggad, E Kalie, EL Ooi, F Sun, FF Yu, J Zou, J Zou, J Zou, J Zou, JM Gonzalez-Navajas, Jun Zou, Karen L. Mossman, KE Taylor, M Chang, M Shin-Ya, Ming-Xian Chang, MK Purcell, N Sathish, O Haller, OJ Hamming, PE Phelan, Pin Nie, S Biacchesi, S Campbell, S Long, S Long, SA Martin, SV Kotenko, SY Liu, T Svingerud, V Bergan, Y Palti, YB Zhang, Z Li, Z Qi, Zhanglong Yu   +45 more
core   +3 more sources

Peptide agonists of the thrombopoietin receptor [PDF]

Stem Cells, 1998
We have screened a variety of L-amino acid peptide libraries against the extracellular domain of the human thrombopoietin (HuTPO) receptor, c-Mpl. A large number of peptide ligands were recovered and categorized into two families. Peptides from each family compete with the binding of HuTPO and with the binding of peptides from the other familiy ...
W J, Dower, S E, Cwirla, P, Balasubramanian, P J, Schatz, D P, Baccanari, R W, Barrett   +5 more
openaire   +2 more sources

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors*

Journal of Biological Chemistry, 2012
Background: The α-hemoglobin-derived peptide RVDPVNFKLLSH was found to interact with cannabinoid CB1 receptors. Results: We generated mAbs against RVDPVNFKLLSH and identified a new family of endogenous peptides (Pepcans) that act as negative allosteric ...
M. Bauer, A. Chicca, Marco Tamborrini, D. Eisen, Raissa Lerner, B. Lutz, O. Poetz, G. Pluschke, J. Gertsch   +8 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Plant Leucine-Rich Repeat Receptor Kinase (LRR-RK): Structure, Ligand Perception, and Activation Mechanism

Molecules, 2019
In recent years, secreted peptides have been recognized as essential mediators of intercellular communication which governs plant growth, development, environmental interactions, and other mediated biological responses, such as stem cell homeostasis ...
Sayan Chakraborty, Brian Nguyen, Syed Danyal Wasti, Guozhou Xu   +3 more
doaj   +1 more source

Nezara viridula (Hemiptera: Pentatomidae) transcriptomic analysis and neuropeptidomics [PDF]

, 2018
Stinkbugs (Hemiptera: Pentatomidae) are of major economic importance as pest of crops. Among the species composing the stinkbug complex, Nezara viridula is one of the most abundant in Brazil, Argentina and the Southern USA. However, this species has been
Catalano, María Inés, Esponda Behrens, Natalia Irene, Lavore, Andres Esteban, Ons, Sheila, Palacio, Victorio Gabriel, Pérez Gianmarco, Lucila Maité, Rivera Pomar, Rolando   +6 more
core   +2 more sources