Results 11 to 20 of about 4,287,179 (359)
Targeting of peptide‐binding receptors on cancer cells with peptide‐drug conjugates
, 2020 Specifically addressing cell surface molecules on cancer cells facilitates targeted cancer therapies that offer the potential to selectively destroy malignant cells, while sparing healthy tissue.
Dennis J Worm +2 more
semanticscholar +1 more source
Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2
ACS Nano, 2020 Peptide inhibitors against the SARS-CoV-2 coronavirus, currently causing a worldwide pandemic, are designed and simulated. The inhibitors are mostly formed by two sequential self-supporting α-helices (bundle) extracted from the protease domain (PD) of ...
Yanxiao Han, P. Král
semanticscholar +1 more source
Journal of Biological Chemistry, 1990 Muscarinic acetylcholine receptors (mAChR) were purified from rat brain and labeled either with the site-directed affinity label [3H]propylbenzilylcholine mustard (PrBCM) or with the sulfhydryl-specific label [3H]N-ethylmaleimide (NEM), using a protocol ...
E. Kurtenbach +5 more
semanticscholar +1 more source
Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions.
Chemistry and Biology, 1996 Opiate receptors mediate the physiological actions of opioid peptides and the clinical effects of the synthetic opioid agonists and antagonists. Site-directed mutagenesis studies have revealed regions of opiate receptors that are essential for ligand ...
Allan D. Blake +2 more
semanticscholar +1 more source
Biomolecules, 2020 The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this peptide after its oral administration.
Anna Mas-Capdevila +5 more
doaj +1 more source
Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro [PDF]
, 2003 The growth rate of numerous cancer cell lines is regulated in part by actions of neuropeptides of the vasoactive intestinal peptide (VIP) family, which also includes pituitary adenylate cyclase-activating peptide (PACAP), glucagon, and peptide histidine ...
Alleaume, Céline +4 more
core +1 more source
Peptide Receptor Radionuclide Therapy
The Journal of Clinical Endocrinology & Metabolism, 2022 Abstract The concept of using a targeting molecule labeled with a diagnostic radionuclide for using positron emission tomography or single photon emission computed tomography imaging with the potential to demonstrate that tumoricidal radiation can be delivered to tumoral sites by administration of the same or a similar targeting molecule
Johannes Hofland +4 more
openaire +3 more sources
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition
Molecules, 2017 The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide ...
Hui-qiong He, R. Ye
semanticscholar +1 more source
The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]
, 2013 Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József +7 more
core +13 more sources
Does kisspeptin belong to the proposed RF-amide peptide family?
Frontiers in Endocrinology, 2014 Kisspeptin (KISS) plays a key role in regulating reproduction by binding to its receptor, GPR54 (KISSR). Because of the Arg-Phe (RF) sequence at its carboxyl terminus, KISS has been proposed to be a member of the RF-amide peptide family consisting of ...
Seongsik eYun +5 more
doaj +1 more source