Results 11 to 20 of about 103,363 (247)

Adult-Onset Still’s Disease—A Complex Disease, a Challenging Treatment

International Journal of Molecular Sciences, 2022
Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder with an unknown cause characterized by high-spiking fever, lymphadenopathy, hepatosplenomegaly, hyperferritinemia, and leukocytosis.
L. Macovei, A. Burlui, I. Bratoiu, C. Rezus, A. Cardoneanu, P. Richter, A. Szalontay, E. Rezuș   +7 more
semanticscholar   +1 more source

The association between adult-onset Still’s disease and collapsing glomerulopathy: a case report

Journal of Medical Case Reports, 2022
Background Collapsing glomerulopathy, characterized by marked hypertrophy and hyperplasia of the podocytes with eventual collapse of the glomerular tuft, is an important cause of end-stage renal disease. Among the many causes of collapsing glomerulopathy,
Matas Orentas, Nilam Patel, Roger Rodby, Sobia Hassan   +3 more
doaj   +1 more source

Adult-onset Still's Disease: A Case Report

Journal of Nepal Medical Association, 2020
Adult-onset Still’s Disease is a rare auto inflammatory disorder of unknown etiology characterized mainly by high spiking fever, arthritis, evanescent rash and lymphadenopathy.
Ashok Sapkota, Nirdesh Pokhrel, Jayaram Adhikari, Bishal Shrestha, Yoveen Kumar Yadav   +4 more
doaj   +3 more sources

Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach

Journal of Clinical Medicine, 2021
Adult-onset Still’s disease (AoSD) is a rare systemic autoinflammatory disease characterized by arthritis, spiking fever, skin rash and elevated ferritin levels.
Stylianos Tomaras, Carl Christoph Goetzke, T. Kallinich, E. Feist   +3 more
semanticscholar   +1 more source

Mechanisms, biomarkers and targets for adult-onset Still’s disease

Nature Reviews Rheumatology, 2018
Adult-onset Still’s disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with potentially severe inflammatory onset accompanied by a broad spectrum of ...
E. Feist, S. Mitrovic, B. Fautrel
semanticscholar   +1 more source

Therapy with canakinumab for adult-onset still's disease

Научно-практическая ревматология, 2019
Still's disease in children (systemic-onset juvenile idiopathic arthritis, SoJIA) and in adults (adult-onset Still's disease) are considered as non-familial systemic autoinflammatory diseases of unknown etiology driven by similar immunopathogenetic ...
E. L. Nasonov
doaj   +1 more source

Canakinumab for Treatment of Adult-Onset Still’s Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial

Annals of the Rheumatic Diseases, 2020
Background Inhibition of interleukin (IL)-1 represents a promising treatment option in adult-onset Still's disease (AOSD). Objective To investigate the efficacy and safety of canakinumab in patients with AOSD and active joint involvement by means of a ...
C. Kedor, J. Listing, J. Zernicke, A. Weiß, F. Behrens, N. Blank, J. Henes, J. Kekow, A. Rubbert-Roth, H. Schulze-Koops, E. Seipelt, C. Specker, E. Feist   +12 more
semanticscholar   +1 more source

Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease

Annals of the Rheumatic Diseases, 2017
Objectives Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease; its management is largely empirical. This is the first clinical study to determine if interleukin (IL)-18 inhibition, using the recombinant human IL-18 binding ...
C. Gabay, B. Fautrel, J. Rech, F. Spertini, E. Feist, I. Kötter, E. Hachulla, J. Morel, T. Schaeverbeke, M. Hamidou, T. Martin, B. Hellmich, P. Lamprecht, H. Schulze-Koops, D. Courvoisier, A. Sleight, E. Schiffrin   +16 more
semanticscholar   +1 more source

Clinical Phenotypes of Adult-Onset Still’s Disease: New Insights from Pathophysiology and Literature Findings

Journal of Clinical Medicine, 2021
Adult-onset Still’s disease (AOSD) is a non-familial, polygenic systemic autoinflammatory disorder. It is traditionally characterized by four cardinal manifestations—spiking fever, an evanescent salmon-pink maculopapular rash, arthralgia or arthritis and
S. Mitrovic, B. Fautrel
semanticscholar   +1 more source

Adult-Onset Still’s Disease Presenting as Macrophage-Activation Syndrome With Critical Illness in the Third Trimester of Pregnancy: A Case Report

Critical Care Explorations, 2021
BACKGROUND:. We report a case of a young woman with adult-onset Still’s disease presenting as macrophage-activation syndrome complicated by shock and respiratory failure during the third trimester of pregnancy. CASE SUMMARY:. A previously healthy 26-year-
Andrew T. Peters, MD, Michelle H. Prickett, MD   +1 more
doaj   +1 more source