Results 51 to 60 of about 5,437 (266)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Outcomes and organ dysfunctions of critically ill patients with systemic lupus erythematosus and other systemic rheumatic diseases [PDF]

, 2011
Our objective was to compare the pattern of organ dysfunctions and outcomes of critically ill patients with systemic lupus erythematosus (SLE) with patients with other systemic rheumatic diseases (SRD).
AZEVEDO, L.C.P., BATTAINI, L.C., GIANNINI, F.P., MORAES, C.E., PARK, M., PINAFFI, J.V., PRADA, L.F.L., RANZANI, O.T., SHINJO, S.K.   +8 more
core   +5 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Septic arthritis or adult-onset still’s disease: analyzing the causes of recurrent fever after arthroscopic combined anterior cruciate ligament and posterior cruciate ligament reconstruction: a case report

BMC Musculoskeletal Disorders
Background Adult-onset still’s disease and septic arthritis share similar symptoms—fever, joint pain, and limited mobility—making postoperative diagnosis difficult after combined anterior cruciate ligament and posterior cruciate ligament reconstruction ...
Zenan Tian, Jianlong Ni, Wang Wei, Qichun Song, Shanshan Liu, Dongjian Wang, Ruiying Li, Dazhi Wang, Zhihao Chen, Zhikun Jia, Jiajun Jiang, Zhibin Shi   +11 more
doaj   +1 more source

Noncaseating suppurative granulomatous lymphadenitis in adult onset Still’s disease – a diagnostic dilemma in a tuberculosis-endemic region: a case report

Journal of Medical Case Reports, 2018
Background Lymphadenopathy is not an uncommon presentation of adult onset Still’s disease: it is present in up to two thirds of patients with adult onset Still’s disease.
S. W. G. J. W. Chinthaka, R. L. Satarasinghe, S. Senanayake, W. A. P. S. R. Weerarathne, A. A. M. Anfaz, M. P. Deraniyagala   +5 more
doaj   +1 more source

Clarithromicin in adult-onset Still'disease a study of 6 cases [PDF]

, 2010
Adult-onset Still's disease (AOSD) is a rare rheumatological condition characterized by an acute systemic involvement. There are no treatment guidelines.
Abdi-Ali, L, Baiardi, P, Benucci, M, Bucci, M, Cirino, G, Manfredi, M, Saviola, G   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still’s disease: a case report

Journal of Medical Case Reports, 2012
Introduction Isolated hepatic tuberculosis is an uncommon manifestation of one of the most common infections worldwide, caused by Mycobacterium tuberculosis. Extremely high serum ferritin, which is regarded as a marker of adult onset Still’s disease, has
Manoj Edirisooriya, Srigrishna Rajini, Ragunathan Murugapillai K   +2 more
doaj   +1 more source