Results 131 to 140 of about 701,750 (333)

The quality and relevance of staff training to deliver adult basic education (ABE) and English for speakers of other languages (ESOL) [PDF]

open access: yes, 2010
"This report is published in response to a request in the annual Ministerial remit to Estyn for 2009-2010 to evaluate the quality and relevance of staff training to deliver ABE and ESOL...

core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

青少年數位裝置使用時間、媒體多工與認知功能及心理適應間的關聯性 The Relationship Between Screen Time, Media Multitasking and Executive Functions in Adolescents

open access: yesJournal of Research in Education Sciences
本研究旨在調查臺灣青少年媒體多工的現況和探討其與認知功能及心理適應間的相關性。本研究招募12-15歲自願者參與研究,有效樣本數為291人。參與者須填答媒體多工量表、巴拉特衝動量表、心理憂鬱量表與生活滿意度量表,並以電腦化測驗評估工作記憶廣度、注意力、轉換能力、抑制功能。本研究結果發現:一、臺灣青少年數位裝置使用平均時間為每週30.98小時、媒體多工的平均分數值為2.26。二、數位裝置使用時間與工作記憶廣度、轉換能力、注意力之警覺、導引、執行控制之間沒有相關,但與注意力的反應時間有負相關。三 ...
陳佳欣 Chia-Hsin Chen   +1 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Returning to Learning: Adults' Success in College Is Key to America's Future [PDF]

open access: yes, 2007
Provides an overview of research on adult learners' characteristics, risk factors, and needs at four-year institutions and in for-credit and non-credit courses, and what changes institutions and governments can implement to help adult students ...
Brian Pusser   +6 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Institutional factors affecting teachers’ effectiveness in rural primary schools

open access: yesInternational Journal of Educational Management and Development Studies
This study explored the institutional factors affecting teachers’ effectiveness in rural primary schools in the Tshwane North District of Gauteng Province, South Africa.
Vhurande Dadirai , Thulani Andrew Chauke
doaj   +1 more source

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