Results 71 to 80 of about 6,519,330 (307)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Coronavirus disease 2019 in patients with Fontan circulation

International Journal of Cardiology Congenital Heart Disease, 2021
Flavia Fusco, Giancarlo Scognamiglio, Assunta Merola, Michela Palma, Anna Correra, Nunzia Borrelli, Rosaria Barracano, Nicola Grimaldi, Diego Colonna, Emanuele Romeo, Berardo Sarubbi   +10 more
doaj   +1 more source

Feasibility and effectiveness of telemedicine for adult patients with congenital heart disease: A one-year single-center experience-based studySummary table

International Journal of Cardiology Congenital Heart Disease
Introduction: The number of adults with congenital heart disease has significantly increased in recent years. While telemedicine has emerged as a promising approach to improve care delivery and patient outcomes, its use for adults with congenital ...
Nunzia Borrelli, Nicola Grimaldi, Flavia Fusco, Antonio Orlando, Michela Palma, Maria Cristina Boccia, Sabrina Bassolino, Anna Iervolino, Berardo Sarubbi   +8 more
doaj   +1 more source

Arrhythmias in adults with congenital heart disease [PDF]

Heart, 2002
Refinement of surgical techniques for the treatment of congenital heart disease (CHD) has created a new population of young adults with heart disease. In the USA, it is estimated that there are nearly one million CHD patients, 15–20% with disease of severity to warrant surgical intervention. As surgical mortality has fallen, the number of adults living
openaire   +2 more sources

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Factors associated with cardiovascular events after simultaneous liver–kidney transplant from the US Multicenter Simultaneous Liver–Kidney Transplant Consortium

Hepatology Communications, EarlyView., 2022
Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo, Gonzalo Crespo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min Zhang, John Magee, Pranab Barman, Yuval A. Patel, Aaron Schluger, Kara Walters, Scott Biggins, Natalia Filipek, Giuseppe Cullaro, Randi Wong, Jennifer C. Lai, Gabriel J. Perreault, Elizabeth C. Verna, Pratima Sharma, Lisa B. VanWagner   +19 more
wiley   +1 more source

Hospitalization Trends and Health Resource Use for Adult Congenital Heart Disease–Related Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background This study assessed trends in heart failure (HF) hospitalizations and health resource use in patients with adult congenital heart disease (ACHD).
Luke J. Burchill, Lina Gao, Adrienne H. Kovacs, Alexander R. Opotowsky, Bryan G. Maxwell, Jessica Minnier, Abigail M. Khan, Craig S. Broberg   +7 more
doaj   +1 more source

Heart Transplantation in Adults with Congenital Heart Disease

Methodist DeBakey Cardiovascular Journal, 2019
Steady advances in the diagnosis and management of congenital heart disease over the last few decades has resulted in a growing population of adults with congenital heart disease (ACHD). Consequently, there has been a parallel increase in the number of ACHD patients plagued with end-stage heart failure.
openaire   +2 more sources

Healthcare system inputs and patient-reported outcomes: a study in adults with congenital heart defect from 15 countries [PDF]

, 2020
BACKGROUND: The relationship between healthcare system inputs (e.g., human resources and infrastructure) and mortality has been extensively studied. However, the association between healthcare system inputs and patient-reported outcomes remains unclear ...
Sluman, MA, Fernandes, Susan M, APPROACH-IS consortium and ISACHD, Oechslin, Erwin, Soufi, Alexandra, Sluman, Maayke A, White, Kamila S,, Apers, Silke,, Cook, SC, Thomet, C, Goossens, Eva,, Soufi, Alexandra,, Kutty, Shelby, Chidambarathanu, Shanthi,, Moons, P, Callus, Edward, Jackson, JL, Cook, Stephen C, Fernandes, Susan M., Chidambarathanu, S, Lu, Chun-Wei, Soufi, A, Eriksen, Katrine, Mackie, Andrew S,, Mackie, Andrew S., Dellborg, Mikael,, Khairy, Paul,, Jackson, Jamie L., Van Bulck, L, Khairy, P, Johansson, B, Jackson, Jamie L,, Luyckx, K, Lu, CW, Goossens, Eva, Khairy, Paul, Mackie, Andrew S, Oechslin, E, Fernandes, SM, Lu, Chun-Wei,, Veldtman, Gruschen, Johansson, Bengt,, Menahem, Samuel,, Eriksen, K, Oechslin, Erwin,, Eriksen, Katrine,, Luyckx, Koen, Caruana, Maryanne, Menahem, S, Luyckx, Koen,, Apers, Silke, Veldtman, G, Moons, Philip,, Dellborg, Mikael, Enomoto, Junko,, Budts, Werner,, Enomoto, Junko, Menahem, Samuel, Alday, Luis,, White, Kamila, Moons, Philip, Alday, L, Veldtman, Gruschen,, Sluman, Maayke A,, Callus, Edward,, Goossens, E, Thomet, Corina, Sluman, Maayke A., Enomoto, J, Dellborg, M, Alday, Luis, Budts, W, Van Bulck, Liesbet,, Budts, Werner, Berghammer, M, Thomet, Corina,, Van Bulck, Liesbet, Berghammer, Malin, Caruana, M, White, K, MacKie, AS, Chidambarathanu, Shanthi, Fernandes, Susan M,, Kutty, Shelby,, Kutty, S, Apers, S, Callus, E, Cook, Stephen C,, Cook, Stephen C., Caruana, Maryanne,, Berghammer, Malin,, Johansson, Bengt, Jackson, Jamie L   +92 more
core   +1 more source