Results 51 to 60 of about 107,561 (313)

Heart transplantation in adults with congenital heart disease

Archives of Cardiovascular Diseases, 2017
With the advances in congenital cardiac surgery and postoperative care, an increasing number of children with complex congenital heart disease now reach adulthood. There are already more adults than children living with a congenital heart defect, including patients with complex congenital heart defects. Among these adults with congenital heart disease,
Lucile, Houyel, Ngoc-Tram, To-Dumortier, Yannick, Lepers, Jérôme, Petit, Régine, Roussin, Mohamed, Ly, Emmanuel, Lebret, Elie, Fadel, Jürgen, Hörer, Sébastien, Hascoët   +9 more
openaire   +2 more sources

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Long-term healthcare utilization, medical cost, and societal cost in adult congenital heart disease

, 2020
Objective: Cost-of-illness studies in Adult Congenital Heart Disease (ACHD) have mainly been limited to hospitalizations. This is the first paper to provide a comprehensive overview from a societal perspective including inpatient and outpatient medical ...
Annemans, Lieven, Moniotte, S., Ombelet, F., Moons, Philip, Budts, Werner, de Hosson, M., Marelli, A., De Backer, Julie, Annemans, L., Van Bulck, Liesbet, Willems, R., de Hosson, Michèle, Goossens, E., Moons Julie De Backer, Philip, Budts, W., Van Bulck, L., De Groote, Katya, Goossens, Eva, Marelli, Arianne, De Groote, K., Willems, Ruben, Ombelet, Fouke, De Backer, J., Moniotte, Stéphane, Moons, Philip,   +24 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Home-based interval training increases endurance capacity in adults with complex congenital heart disease

, 2017
Objective: The beneficial effects of exercise training in acquired heart failure and coronary artery disease are well known and have been implemented in current treatment guidelines.
Öhrn, Amanda, Sandberg, C., Anders Ahnfelt, Sandberg, Camilla,, Wadell, K., Bengt Johansson, Johansson, B., Hedström, Magnus,, Magnus Hedström, Wadell, Karin,, Johansson, Bengt,, Ahnfelt, Anders, Hedstrom, M., Ahnfelt, Anders,, Mikael Dellborg, Zetterström, Anna-Klara, Karin Wadell, Amanda Öhrn, Dellborg, Mikael, Ohrn, A., Zetterstrom, A. K., Camilla Sandberg, Dellborg, Mikael,, Anna-Klara Zetterström   +23 more
core   +1 more source

Sudden cardiac death in adults with congenital heart disease: Lessons to Learn from the ATROPOS registry

International Journal of Cardiology Congenital Heart Disease, 2022
Sudden cardiac death (SCD) is one of the most frequent causes of death in adult patients with congenital heart disease (ACHD). Despite the rare frequency of its occurrence, the incident appears often when unexpected, and many affected patients had not ...
Alicia Jeanette Fischer, Ulrike MM. Bauer, Michael Frey, Jens Beudt, Helmut Baumgartner, Gerhard-Paul Diller   +5 more
doaj   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Surgery for Adult Patients with Congenital Heart Disease: Results from the European Database [PDF]

, 2020
Adults with congenital heart disease (ACHD) represent a growing population. To evaluate frequency, type and outcomes of cardiac surgery in ACHD, we gathered data from the European Congenital Heart Surgeons Association Database of 20,602 adult patients ...
Vladimiro Vida, Tobota, Zdzislaw, Tjark Ebels, Horer, Jurgen, Lorenza Zanotto, Francesco Bertelli, Lucia Zanotto, Ebels, Tjark, Di Salvo, Giovanni, Maruszewski, Bohdan, Sarris, George, on the behalf of the European Congenital Heart Surgeons Association (ECHSA), Claudia Cattapan, Gregori, Dario, Padalino, Massimo A, Laura Torlai Triglia, On The Behalf Of The European Congenital Heart Surgeons Association Echsa, null, Daniele Bottigliengo, Ebels, Tjark; id_orcid, Dario Gregori, Bottigliengo, Daniele, Bohdan Maruszewski, Padalino, Massimo A., Zdzislaw Tobota, Zanotto, Lorenza, Jurgen Horer, Zanotto, Lucia, Bertelli, Francesco, Cattapan, Claudia, Giovanni Stellin, Vida, Vladimiro L, Triglia, Laura Torlai, Vida, Vladimiro L., Stellin, Giovanni, Torlai Triglia, Laura, Giovanni Di Salvo, George Sarris, Massimo Padalino   +37 more
core   +1 more source

Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: A Single-Center Retrospective Study [PDF]

, 2021
Purpose: This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD).
정세용, 최재영, 김아영, 정조원   +3 more
core   +1 more source

Pregnancy in women with left-to-right cardiac shunts: Any risk?

International Journal of Cardiology Congenital Heart Disease, 2021
An unacceptably high incidence of maternal mortality and morbidity, often due to cardiovascular disease, has been recently identified in developed nations with a call to action to improve maternal health and outcomes for both mother and baby.
Marla A. Mendelson
doaj   +1 more source