Results 41 to 50 of about 107,561 (313)

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Healthcare system inputs and patient-reported outcomes: a study in adults with congenital heart defect from 15 countries [PDF]

, 2020
BACKGROUND: The relationship between healthcare system inputs (e.g., human resources and infrastructure) and mortality has been extensively studied. However, the association between healthcare system inputs and patient-reported outcomes remains unclear ...
Sluman, MA, Fernandes, Susan M, APPROACH-IS consortium and ISACHD, Oechslin, Erwin, Soufi, Alexandra, Sluman, Maayke A, White, Kamila S,, Apers, Silke,, Cook, SC, Thomet, C, Goossens, Eva,, Soufi, Alexandra,, Kutty, Shelby, Chidambarathanu, Shanthi,, Moons, P, Callus, Edward, Jackson, JL, Cook, Stephen C, Fernandes, Susan M., Chidambarathanu, S, Lu, Chun-Wei, Soufi, A, Eriksen, Katrine, Mackie, Andrew S,, Mackie, Andrew S., Dellborg, Mikael,, Khairy, Paul,, Jackson, Jamie L., Van Bulck, L, Khairy, P, Johansson, B, Jackson, Jamie L,, Luyckx, K, Lu, CW, Goossens, Eva, Khairy, Paul, Mackie, Andrew S, Oechslin, E, Fernandes, SM, Lu, Chun-Wei,, Veldtman, Gruschen, Johansson, Bengt,, Menahem, Samuel,, Eriksen, K, Oechslin, Erwin,, Eriksen, Katrine,, Luyckx, Koen, Caruana, Maryanne, Menahem, S, Luyckx, Koen,, Apers, Silke, Veldtman, G, Moons, Philip,, Dellborg, Mikael, Enomoto, Junko,, Budts, Werner,, Enomoto, Junko, Menahem, Samuel, Alday, Luis,, White, Kamila, Moons, Philip, Alday, L, Veldtman, Gruschen,, Sluman, Maayke A,, Callus, Edward,, Goossens, E, Thomet, Corina, Sluman, Maayke A., Enomoto, J, Dellborg, M, Alday, Luis, Budts, W, Van Bulck, Liesbet,, Budts, Werner, Berghammer, M, Thomet, Corina,, Van Bulck, Liesbet, Berghammer, Malin, Caruana, M, White, K, MacKie, AS, Chidambarathanu, Shanthi, Fernandes, Susan M,, Kutty, Shelby,, Kutty, S, Apers, S, Callus, E, Cook, Stephen C,, Cook, Stephen C., Caruana, Maryanne,, Berghammer, Malin,, Johansson, Bengt, Jackson, Jamie L   +92 more
core   +1 more source

Cap‐oPMN: Oral Inflammatory Load Quantification Using Capillary Microfluidics and Automated Image Processing

Advanced Materials Technologies, EarlyView.
ABSTRACT Quantifying oral polymorphonuclear neutrophils (oPMNs) is a clinically validated approach for assessing periodontal inflammation. However, current methods, such as manual hemocytometry and flow cytometry, are time‐consuming (>3 h), require invasive sampling, and depend on staining and complex instrumentation, making them unsuitable for point ...
Mohsen Hassani, Azam Zare, Fatemeh Soheili, S. M. Mahdi H. Daneshvar, Mahdi Amrollahi Biouki, Yasaman Tahernezhad, Chunxiang Sun, Michael Glogauer, Ebrahim Ghafar‐Zadeh, Amir Sanati‐Nezhad   +9 more
wiley   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Rehabilitation program in adult congenital heart disease patients with pulmonary hypertension

, 2010
Introduction. It is commonly believed that physical activity may have a negative impact on pulmonary hypertension patients. The object of this study is to determine the tolerability of a directed exercise program in congenital heart disease patients with
Miranda Calderín, Guillermo, Ugarte-Lopetegui, Arantza, Rodríguez-González, Fayna, Martínez Quintana, Efrén   +3 more
core   +1 more source

Imaging the heart in adult congenital heart disease [PDF]

Heart, 1998
Over the past two decades most congenital cardiac lesions have become amenable to surgical repair. The trend is to perform more anatomical types of repair at an earlier age. In addition, older patients, who were previously only palliated, present for corrective surgical interventions.
openaire   +2 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Mental health in adult congenital heart disease

, 2023
Mental health issues are common in individuals with congenital heart disease (CHD), stemming from various factors such as traumatic experiences, existential questions, and genetic predisposition.
Bo Daelman, Luyckx, Koen, Daelman, Bo, Moons, Philip, Philip Moons, Liesbet Van Bulck, Moons, Philip,, Koen Luyckx, Van Bulck, Liesbet   +8 more
core   +1 more source

Pulmonary arterial hypertension with left to right shunts: When to treat and/or close?

International Journal of Cardiology Congenital Heart Disease
Pulmonary arterial hypertension (PAH) is defined as increase in mean pulmonary arterial pressure and pulmonary vascular resistance (PVR). It can be associated with congenital heart disease (CHD) with the following subtypes: 1) uncorrected left-to-right ...
Michele D'Alto, Emanuele Romeo, Paola Argiento, Andrea Vergara, Eleonora Caiazza, Antonio Orlando, Rosa Franzese, Giancarlo Scognamiglio, Berardo Sarubbi, Konstantinos Dimopoulos   +9 more
doaj   +1 more source

Adult congenital heart disease

Current Opinion in Cardiology, 1994
There are approximately 500,000 adults in the United States with congenital heart disease, and this group is growing at 5% per year. Adult cardiologists are, for the most part, poorly trained in the treatment of congenital heart disease; pediatric cardiologists, on the other hand, work in children's hospitals where it is difficult to care for adults ...
openaire   +5 more sources