Results 101 to 110 of about 2,726,223 (303)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Effects of Adult Education Vouchers on the Labor Market: Evidence from a Randomized Field Experiment [PDF]

open access: yes
Lifelong learning is often promoted in ageing societies, but little is known about its returns or governments’ ability to advance it. This paper evaluates the effects of a large-scale randomized field experiment issuing vouchers for adult education in ...
Dolores Messer   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Beyond the classroom: following the destination of Haramaya University graduates in the real world, Ethiopia

open access: yesCogent Education
This study delves into the perspectives of Haramaya University (HU) graduates regarding their competence, employment prospects, and career advancement.
Yilfashewa Seyoum   +3 more
doaj   +1 more source

Adult education needs inventory: Construction and application. [PDF]

open access: yesFront Psychol, 2022
Ślósarz L   +3 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Children’s Voice in “Nurseries of Democracy“. Participation in Early Childhood Institutions

open access: yesSocial Work and Society, 2018
According to the UN Conventions on the Rights of the Child all children have a right to participation. This UN Convention has influenced professionals and policy-makers worldwide.
Alexandra Klein, Sandra Landhäußer
doaj  

PREPARATION OF BECOMING TEACHERS OF AGRICULTURE FOR FILLING THE PART OF AN ADULT EDUCATOR [PDF]

open access: yes
All becoming teachers would need knowledge on adult education in order to better understand his own lifelong learning. If adult education were integrated into university education of BSc or MSc level, extension courses for practicing teachers would not ...
Fekete-Szakos, Eva
core   +1 more source

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