Results 91 to 100 of about 1,014,159 (263)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Avoiding pitfalls in the next International Conference on Adult Education (CONFINTEA): Lessons on financing adult education from Belém. [PDF]
Int Rev Educ, 2022 Archer D.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Journal of Research in Education Sciences隨著臺灣即將進入超高齡社會，如何讓屆退民眾預先做好退休準備、確保退休生活品質，是當前臺灣高齡社會一項重要課題。本研究目的在以退休前10年的公教人員為研究對象，透過翻轉教學實驗瞭解學習需求與實際學習效果的差距，再藉由退休準備教育課程需求現況調查，瞭解不同需求課程實施翻轉教學策略的成效，進而調整出適合屆退族群的退休課程與教學策略，以培養其充足的退休知識與應用能力，做好前瞻因應的退休準備。本研究採用問卷調查法進行需求調查，研究設計採分層隨機抽樣，研究工具「臺灣退休準備教育課程需求指標 ...
胡夢鯨 Menq-Jing Hwu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Children’s Voice in “Nurseries of Democracy“. Participation in Early Childhood Institutions
Social Work and Society, 2018 According to the UN Conventions on the Rights of the Child all children have a right to participation. This UN Convention has influenced professionals and policy-makers worldwide.
Alexandra Klein, Sandra Landhäußer
doaj
Journal of Research in Education Sciences青銀世代對數位遊戲的使用動機具差異性，而數位遊戲的開發或設計往往無法為所有年齡層量身定做，例如長者對於規則太複雜、時間太緊湊的遊戲設計有負面的認知，但年輕人反而追求遊戲的效率。此外，過去探討不同世代數位遊戲設計及功能評估的研究，大多為受試者自陳、觀察和訪談方法蒐集主動意識層面的資料，較少透過語意聯想這類的結果探究。 據此，本研究欲以數位遊戲認知的語意聯想測驗（Word Association Test, WAT）蒐集多元的資料以探討世代間之異同。本研究以便利取樣招募178位不同年齡層的對象 ...
劉智淇 Chih-Chi Liu +1 more
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Dropout in youth and adult education: a multilevel analysis of students and schools in Chile. [PDF]
Front Psychol, 2023 Contreras-Villalobos T +3 more
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source