Results 71 to 80 of about 1,014,159 (263)
Journal of Innovation and EntrepreneurshipThe integration of digital technologies (DT) into informal entrepreneurship (IE) is increasingly recognized as a critical driver of economic productivity, market accessibility and operational efficiency, particularly in developing economies.
Abigail A. Aryeh-Adjei +3 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2019 Gramsci’s significance for education lies in two realms. First, his notion of hegemony provides a way of understanding in which informal educators function and it gives us the possibility of critique and transformation. His theory of organic intellectuals provides a more detailed place of adult education in his thought. The intellectuals have a crucial
TOPRAK, Ziya, YÜCEL, Volkan
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Frontiers in EducationBackgroundGlobalization plays a pivotal role in shaping adult and higher education across the regions of the world, driven by rapid technological advancement, the diffusion of knowledge, and expanding cross-border educational practices.
Abdulazeez Kolapo Abdullahi +7 more
doaj +1 more source
AS: Andragoška Spoznanja, 2019 Policies on adult literacy and basic education are gaining importance, especially since the results of the OECD Programme for the International Assessment of Adult Competencies (PIAAC) revealed that a sizeable proportion of adults have low literacy ...
Alexandra Ioannidou, Carolin Knauber
doaj +1 more source