Results 71 to 80 of about 10,032,022 (290)
Multidisciplinary Journal of School Education, 2017 This study dealt with the role of the Postgraduate Diploma in Secondary School Teaching (PGDT) program in improving the quality of teaching in Eastern Ethiopian secondary schools.
Sisay Wondemetegegn +2 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Innovation and EntrepreneurshipThe integration of digital technologies (DT) into informal entrepreneurship (IE) is increasingly recognized as a critical driver of economic productivity, market accessibility and operational efficiency, particularly in developing economies.
Abigail A. Aryeh-Adjei +3 more
doaj +1 more source
Engagement of older adults in higher education: International perspectives from New Zealand and Scotland [PDF]
, 2012 This article explores the issue of older adults’ access to and participation in higher education in two countries, Aotearoa New Zealand and Scotland. It discusses older adults’ engagement with regard to patterns of participation and provision, using a ...
Findsen, Brian
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Chapter Advocacy, Adult Learning and the Pursuit of Social Justice
, 2023 The chapter highlights the centrality of advocacy work for adult learners, particularly from marginalised and excluded communities, as a key feature of the work of Lalage Bown and its scope nationally and internationally.
Tuckett, Alan
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Frontiers in EducationBackgroundGlobalization plays a pivotal role in shaping adult and higher education across the regions of the world, driven by rapid technological advancement, the diffusion of knowledge, and expanding cross-border educational practices.
Abdulazeez Kolapo Abdullahi +7 more
doaj +1 more source