Results 71 to 80 of about 2,726,223 (303)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Adult Education [PDF]

BMJ, 1955
  +6 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Role of the ‘Post Graduate Diploma in Secondary School Teaching’ Program in Improving the Quality of Teaching in Eastern Ethiopian Secondary Schools

Multidisciplinary Journal of School Education, 2017
This study dealt with the role of the Postgraduate Diploma in Secondary School Teaching (PGDT) program in improving the quality of teaching in Eastern Ethiopian secondary schools.
Sisay Wondemetegegn, Anwar Ahmed, Tamrat Zelalem   +2 more
doaj  

Digital technology use and adoption in informal entrepreneurship: evidence from Okere District, Ghana

Journal of Innovation and Entrepreneurship
The integration of digital technologies (DT) into informal entrepreneurship (IE) is increasingly recognized as a critical driver of economic productivity, market accessibility and operational efficiency, particularly in developing economies.
Abigail A. Aryeh-Adjei, Kofi Koranteng Adu, Ama Otwiwah Adu-Marfo, Goldman Awuku   +3 more
doaj   +1 more source

Adult Literacy and Basic Education Policies in a Comparative Perspective: Selected Findings from four Country Cases

AS: Andragoška Spoznanja, 2019
Policies on adult literacy and basic education are gaining importance, especially since the results of the OECD Programme for the International Assessment of Adult Competencies (PIAAC) revealed that a sizeable proportion of adults have low literacy ...
Alexandra Ioannidou, Carolin Knauber
doaj   +1 more source

Learning For Life: The Opportunity For Technology To Transform Adult Education - Part II: The Supplier Ecosystem [PDF]

, 2015
In fall 2014, Tyton Partners (formerly Education Growth Advisors), with support from the Joyce Foundation, conducted national research on the role and potential of instructional technology in the US adult education field.

core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Back to School [PDF]

, 2014
The Back to School of the title refers to post- school or second chance education in America. Mike Rose’s focus is on adult remedial (sic) and occupational education.
Osmond, Pamela
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source