Results 81 to 90 of about 15,062 (213)
Pediatric Discovery, EarlyView.Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang +7 more
wiley +1 more source
Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis [PDF]
, 2017 Hepatoblastoma, the most common type of pediatric liver cancer, is treated with a combination of surgery and chemotherapy. An essential drug in the treatment of hepatoblastoma is doxorubicin, which in high doses is cardiotoxic. This adverse effect is due
Andersson, Leif C. +5 more
core +1 more source
Risk of Cancer With Hormone Replacement Therapy: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue +3 more
wiley +1 more source
Adult Granulosa Cell Tumor Associated with Endometrial Carcinoma
Journal of South Asian Federation of Obstetrics and Gynaecology, 2016 ABSTRACT Adult granulosa cell tumors account for approximately 1 and 2% of all ovarian tumors and 95% of all granulosa cell tumors. They occur more often in postmenopausal than in premenopausal women, with a peak incidence between 50 and 55 years of age. They are the most common estrogenic ovarian tumors diagnosed clinically.
Archana Baser +2 more
openaire +1 more source
Loss and reappearance of gap junctions in regenerating liver [PDF]
, 1978 Changes in intercellular junctional morphology associated with rat liver regeneration were examined in a freeze-fracture study. After a two-thirds partial hepatectomy, both gap junctions and zonulae occludentes were drastically altered.
Revel, J.-P., Yee, A. G.
core +2 more sources
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis
Andrology, EarlyView.ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan +10 more
wiley +1 more source
YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors [PDF]
Endocrine-Related Cancer, 2014 The Hippo signaling pathway has been implicated as a conserved regulator of organ size in bothDrosophilaand mammals. Yes-associated protein (YAP), the central component of the Hippo signaling cascade, functions as an oncogene in several malignancies. Ovarian granulosa cell tumors (GCT) are characterized by enlargement of the ovary, excess production of
David, Fu +9 more
openaire +2 more sources
Extragonadal LH/hCG action-Not yet time to rewrite textbooks [PDF]
, 2007 Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of ...
Ahtiainen, Petteri +5 more
core +3 more sources
Women in space: A review of known physiological adaptations and health perspectives
Experimental Physiology, EarlyView.Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford +4 more
wiley +1 more source
Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice [PDF]
, 2016 Women with endometriosis can suffer from decreased fecundity or complete infertility via abnormal oocyte function or impaired placental-uterine interactions required for normal pregnancy establishment and maintenance.
Broaddus, Russell +4 more
core +1 more source