Results 91 to 100 of about 110,453 (370)

The link between microglia and adult hippocampal neurogenesis provides a new target for the intervention and treatment of neurodegenerative diseases [PDF]

BIO Web of Conferences
Adult hippocampal neurogenesis (AHN) is closely related to hippocampal plasticity, learning, memory and post-injury repair of the brain. In patients with neurodegenerative diseases, the ability of neural stem cells to proliferate and generate new neurons
Cao Xinyuan
doaj   +1 more source

Energy Restriction Enhances Adult Hippocampal Neurogenesis-Associated Memory after Four Weeks in an Adult Human Population with Central Obesity; a Randomized Controlled Trial

Nutrients, 2020
Adult neurogenesis, the generation of new neurons throughout life, occurs in the subventricular zone of the dentate gyrus in the human hippocampal formation.
Curie Kim, A. Pinto, C. Bordoli, L. P. Buckner, P. C. Kaplan, I. M. Del Arenal, E. J. Jeffcock, W. Hall, S. Thuret   +8 more
semanticscholar   +1 more source

Born to Be Wild: A Case for Targeting Ectopic Adult Born Granule Cells for Seizure Control. [PDF]

, 2020
[Box: see text]
Corrubia, Lucas, Santhakumar, Viji
core  

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

The Role of Adult Hippocampal Neurogenesis in Learning and Memory Function

Türk Nöroloji Dergisi, 2016
Adult hippocampal neurogenesis is the lifelong production of new functional neurons from neural stem cells in the adult brain. Production of neurons in the adult brain is limited to two areas.
Zülal Kaptan, Gülay Üzüm
doaj   +1 more source

Exploring adult hippocampal neurogenesis using optogenetics [PDF]

, 2018
In the 1980s, it was widely accepted that new neurons are continuously generated in the dentate gyrus of the mammalian hippocampus. Since its acceptance, researchers have employed various techniques and behavioral paradigms to study the proliferation ...
Pinardo, Heinrich
core  

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Radiation-induced lowered neurogenesis associated with shortened latency of inhibitory avoidance memory response [PDF]

, 2011
The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works.
Azami, N.S., Heidari, M., Jahanshahi, M., Khoshnazar, A.K.   +3 more
core  

The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner. [PDF]

, 2012
International audienceHyperforin is one of the main bioactive compounds that underlie the antidepressant actions of the medicinal plant Hypericum perforatum (St. John's wort).
Abrous, Djoher Nora, Bouron, Alexandre, Chevallier, Tiphaine, Deloulme, Jean-Christophe, Gibon, Julien, Ladevèze, Elodie   +5 more
core   +3 more sources

Cadmium Exposure Impairs Adult Hippocampal Neurogenesis

Toxicological Sciences, 2019
Abstract Cadmium (Cd) is an environmental pollutant of considerable interest throughout the world and potentially a neurotoxicant. Our recent data indicate that Cd exposure induces impairment of hippocampus-dependent learning and memory in mice. However, the underlying mechanisms for this defect are not known.
Hao, Wang, Glen M, Abel, Daniel R, Storm, Zhengui, Xia   +3 more
openaire   +2 more sources