Results 111 to 120 of about 39,669 (209)

The Timing of Neuronal Development in Adult Hippocampal Neurogenesis

The Neuroscientist, 2006
The granule cell layer (GCL) of the adult dentate gyrus (DG) is a heterogeneous structure formed by neurons of different ages because a significant proportion of neurons continues to be generated throughout life. The subgranular zone of the DG contains neural progenitor cells (NPCs) that divide, differentiate, and migrate to produce functional dentate ...
Piatti, Veronica del Carmen, Esposito, Maria Soledad, Schinder, Alejandro Fabián   +2 more
openaire   +3 more sources

LRP1 in Adult-Born Neural Stem Cells Modulates Neurogenesis and Hippocampal Memory

Cells
(1) Background: Adult neurogenesis within the hippocampus modulates hippocampal memory and is often dysregulated in diseases that cause memory dysfunction, notably Alzheimer’s disease.
Kristi Dietert, Nicole Marion, Meng Wang, Pamela Reed, Erzsebet Kokovay, Naomi L. Sayre   +5 more
doaj   +1 more source

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders

Neural Plasticity, 2012
Adult neurogenesis, the process of generating new neurons from neural stem cells, plays significant roles in synaptic plasticity, memory, and mood regulation.
Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang   +3 more
doaj   +1 more source

Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset

Molecular Brain, 2019
The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely used to treat depression and anxiety disorders. Chronic FLX treatment reportedly induces cellular responses in the brain, including increased adult hippocampal and cortical ...
Koji Ohira, Hideo Hagihara, Miki Miwa, Katsuki Nakamura, Tsuyoshi Miyakawa   +4 more
doaj   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

Absence of Microglial Activation and Maintained Hippocampal Neurogenesis in a Transgenic Mouse Model of Crohn’s Disease

Cells
Adult neurogenesis in the hippocampal dentate gyrus (DG) is not only essential for learning and pattern separation, but it is also involved in emotional regulation. This process is vulnerable to local and peripheral inflammation, which is partly mediated
Rebecca Katharina Masanetz, Hanna Mundlos, Iris Stolzer, Jürgen Winkler, Claudia Günther, Patrick Süß   +5 more
doaj   +1 more source

The futuristic manifolds of REM sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since one of its first descriptions 70 years ago, rapid eye movement sleep has continually inspired and excited new generations of sleep researchers. Despite significant advancements in understanding its neurocircuitry, underlying mechanisms and microstates, many questions regarding its function, especially beyond the early neurodevelopment ...
Liborio Parrino, Ivana Rosenzweig
wiley   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Finding the Words: How Does the Aging Brain Process Language? A Focused Review of Brain Connectivity and Compensatory Pathways

Topics in Cognitive Science, EarlyView.
Abstract As people age, there is a natural decline in cognitive functioning and brain structure. However, the relationship between brain function and cognition in older adults is neither straightforward nor uniform. Instead, it is complex, influenced by multiple factors, and can vary considerably from one person to another.
Monica Baciu, Elise Roger
wiley   +1 more source