Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus. [PDF]
Frontiers in Neuroscience, 2013 Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. Although inducible-reversible transgenic mouse models are increasingly being used to investigate adult
Sebastien eSultan +2 more
doaj +3 more sources
Adult Neurogenesis in Drosophila
Cell Reports, 2013 Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain.
Ismael Fernández-Hernández +2 more
doaj +5 more sources
Testosterone and Adult Neurogenesis [PDF]
Biomolecules, 2020 It is now well established that neurogenesis occurs throughout adulthood in select brain regions, but the functional significance of adult neurogenesis remains unclear. There is considerable evidence that steroid hormones modulate various stages of adult
Mark D. Spritzer, Ethan A. Roy
doaj +3 more sources
Adult Hippocampal Neurogenesis: A Possible Way how Physical Exercise Counteracts Stress [PDF]
Cell Transplantation, 2011 It was considered that neurogenesis only occurred during the embryonic and developmental stage. This view has greatly changed since the discovery of adult neurogenesis in two brain regions: the hippocampus and the olfactory bulb.
Suk-Yu Yau +2 more
doaj +2 more sources
Multimodal insights into adult neurogenesis: An integrative review of multi-omics approaches [PDF]
HeliyonAdult neural stem cells divide to produce neurons that migrate to preexisting neuronal circuits in a process named adult neurogenesis. Adult neurogenesis is one of the most exciting areas of current neuroscience, and it may be involved in a range of ...
Jin Li +8 more
doaj +2 more sources
Computational models of adult neurogenesis [PDF]
Physica A: Statistical Mechanics and its Applications, 2005 Experimental results in recent years have shown that adult neurogenesis is a significant phenomenon in the mammalian brain. Little is known, however, about the functional role played by the generation and destruction of neurons in the context of and adult brain. Here we propose two models where new projection neurons are incorporated.
Cecchi, Guillermo A. +1 more
openaire +3 more sources
New neurons in aging brains: molecular control by small non-coding RNAs [PDF]
Frontiers in Neuroscience, 2012 Adult neurogenesis is a process that continues in the adult and also aging brain. It generates functional neurons from neural stem cells present in specific brain regions.
Marijn eSchouten +3 more
doaj +2 more sources
Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice [PDF]
Nature CommunicationsAdult neurogenesis in the subgranular zone (SGZ) has been implicated in cognitive and affective functions. The role of neuroinflammation and reactive microglia in SGZ neurogenesis is not well understood.
Kierra Ware +12 more
doaj +2 more sources
The intricate interplay between microglia and adult neurogenesis in Alzheimer’s disease [PDF]
Frontiers in Cellular NeuroscienceMicroglia, the resident immune cells of the central nervous system, play a crucial role in regulating adult neurogenesis and contribute significantly to the pathogenesis of Alzheimer’s disease (AD).
Iris Früholz +4 more
doaj +2 more sources
Adult neurogenesis improves spatial information encoding in the mouse hippocampus [PDF]
Nature CommunicationsAdult neurogenesis is a unique form of neuronal plasticity in which newly generated neurons are integrated into the adult dentate gyrus in a process that is modulated by environmental stimuli.
M. Agustina Frechou +7 more
doaj +2 more sources