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Frontiers in Neuroscience, 2022 Postnatal and adult neurogenesis takes place in the dentate gyrus of the hippocampus in the vast majority of mammals due to the persistence of a population of neural stem cells (NSCs) that also generate astrocytes and more NSCs.
Ane Rodríguez-Bodero +4 more
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The EMBO Journal, 2023 Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG).
Oier Pastor-Alonso +11 more
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Cells, 2023 The Neurovascular Unit (NVU), composed of glia (astrocytes, oligodendrocytes, microglia), neurons, pericytes and endothelial cells, is a dynamic interface ensuring the physiological functioning of the central nervous system (CNS), which gets affected and
Evangelia Xingi +8 more
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Stem Cell Reports, 2023 Summary: Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain.
Estefanía Estévez-Priego +5 more
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Neural Regeneration Research, 2022 [INLINE:1] Brain lesions can cause neural stem cells to activate, proliferate, differentiate, and migrate to the injured area. However, after traumatic brain injury, brain tissue defects and microenvironment changes greatly affect the survival and growth
Xuan-Yu Fang +8 more
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Neural Regeneration Research, 2021 Transplantation of neural stem cells (NSCs) can protect neurons in animal stroke models; however, their low rates of survival and neuronal differentiation limit their clinical application.
Sheng-Jun Wen +6 more
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EMBO Molecular Medicine, 2017 Disease modeling with induced pluripotent stem cells (iPSCs) is creating an abundance of phenotypic information that has become difficult to follow and interpret.
Ethan W Hollingsworth +9 more
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Stem Cells International, 2012 Pluripotent stem cells are regarded as a promising cell source to obtain human dopamine neurons in sufficient amounts and purity for cell replacement therapy.
Julio C. Aguila +2 more
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Frontiers in Physiology, 2019 Dental pulp stem cells (DPSCs) have the capacity to give rise to cells with neuronal-like phenotypes, suggesting their use in brain cell therapies. In the present work, we wanted to address the phenotypic fate of adult genetically unmodified human DPSCs ...
Jon Luzuriaga +7 more
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Fast and Efficient Neural Conversion of Human Hematopoietic Cells
Stem Cell Reports, 2014 Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often slow, complex, and inefficient.
Julio Castaño +14 more
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