Results 1 to 10 of about 72,346 (309)

Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies. [PDF]

PLoS ONE, 2015
Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue.
Ellen Binder, Dipa Natarajan, Julie Cooper, Rania Kronfli, Mara Cananzi, Jean-Marie Delalande, Conor McCann, Alan J Burns, Nikhil Thapar   +8 more
doaj   +3 more sources

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest [PDF]

eLife
 The histone methyltransferase Polycomb repressive complex 2 (PRC2) is required for specification of the neural crest, and mis-regulation of neural crest development can cause severe congenital malformations. PRC2 is necessary for neural crest induction,
Tim Casey-Clyde, S John Liu, Angelo Pelonero, Juan Antonio Camara Serrano, Camilla Teng, Yoon-Gu Jang, Harish N Vasudevan, Arun Padmanabhan, Jeffrey Ohmann Bush, David R Raleigh   +9 more
doaj   +2 more sources

History of the study of the neural crest (review)

Сибирский научный медицинский журнал, 2023
The neural crest has long attracted the attention of evolutionary biologists and, more recently, clinical specialists, as research in recent decades has significantly expanded the boundaries of knowledge about the involvement of neural crest and neural ...
N. Yu. Pakhomova, E. L. Strokova, A. A. Korytkin, V. V. Kozhevnikov, A. F. Gusev, A. M. Zaydman   +5 more
doaj   +1 more source

Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

eLife, 2023
During development, much of the enteric nervous system (ENS) arises from the vagal neural crest that emerges from the caudal hindbrain and colonizes the entire gastrointestinal tract.
Jessica Jacobs-Li, Weiyi Tang, Can Li, Marianne E Bronner   +3 more
doaj   +1 more source

Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential

Nature Communications, 2023
The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell
Ceren Pajanoja, Jenny Hsin, Bradley Olinger, Andrew Schiffmacher, Rita Yazejian, Shaun Abrams, Arvydas Dapkunas, Zarin Zainul, Andrew D. Doyle, Daniel Martin, Laura Kerosuo   +10 more
doaj   +1 more source

The origin and evolution of vertebrate neural crest cells [PDF]

Open Biology, 2020
The neural crest is a vertebrate-specific migratory stem cell population that generates a remarkably diverse set of cell types and structures. Because many of the morphological, physiological and behavioural novelties of vertebrates are derived from ...
Joshua R. York, David W. McCauley
doaj   +1 more source

Recent advances in the regulation mechanism of SOX10

Journal of Otology, 2022
Neural crest (NC) is the primitive neural structure in embryonic stage, which develops from ectodermal neural plate cells and epithelial cells. When the neural fold forms into neural tube, neural crest also forms a cord like structure above the neural ...
Jingcui Qi, Long Ma, Weiwei Guo
doaj   +1 more source

Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

eLife, 2022
Production and emigration of neural crest cells is a transient process followed by the emergence of the definitive roof plate. The mechanisms regulating the end of neural crest ontogeny are poorly understood. Whereas early crest development is stimulated
Dina Rekler, Chaya Kalcheim
doaj   +1 more source

Distinct molecular profile and restricted stem cell potential defines the prospective human cranial neural crest from embryonic stem cell state

Stem Cell Research, 2020
Neural crest cells are an embryonic multipotent stem cell population. Recent studies in model organisms have suggested that neural crest cells are specified earlier than previously thought, at blastula stages.
Maneeshi S. Prasad, Rebekah M. Charney, Lipsa J. Patel, Martín I. García-Castro   +3 more
doaj   +1 more source

Protein tyrosine phosphatase 4A3 (PTP4A3) is required for Xenopus laevis cranial neural crest migration in vivo. [PDF]

PLoS ONE, 2013
Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and ...
Selma Maacha, Nathalie Planque, Cécile Laurent, Caterina Pegoraro, Océane Anezo, Frédérique Maczkowiak, Anne H Monsoro-Burq, Simon Saule   +7 more
doaj   +1 more source