Results 41 to 50 of about 1,508,219 (301)
RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells
, 2023 The availability of nucleotides has a direct impact on transcription. Inhibition of dihydroorate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels.
Santoriello, Cristina +18 more
core +1 more source
Beta-actin is required for proper mouse neural crest ontogeny. [PDF]
PLoS ONE, 2014 The mouse genome consists of six functional actin genes of which the expression patterns are temporally and spatially regulated during development and in the adult organism. Deletion of beta-actin in mouse is lethal during embryonic development, although
Davina Tondeleir +3 more
doaj +1 more source
Evolution Letters, 2021 The neural crest hypothesis posits that selection for tameness resulted in mild alterations to neural crest cells during embryonic development, which directly or indirectly caused the appearance of traits associated with the “domestication syndrome” (DS).
Laura A. B. Wilson +4 more
doaj +1 more source
Posteriorizing factor Gbx2 is a direct target of Wnt signalling during neural crest induction [PDF]
, 2015 Wnt signalling is required for neural crest induction; however the direct targets of the Wnt pathway during neural crest induction remain unknown. I show here that the homeobox gene Gbx2 is essential in this process and is directly activated by Wnt/β ...
Li, B
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Annexin a6 modulates chick cranial neural crest cell emigration. [PDF]
PLoS ONE, 2012 The vertebrate neural crest is a population of migratory cells that originates in the dorsal aspect of the embryonic neural tube. These cells undergo an epithelial-to-mesenchymal transition (EMT), delaminate from the neural tube and migrate extensively ...
Chyong-Yi Wu, Lisa A Taneyhill
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Pax7 lineage contributions to the mammalian neural crest.
PLoS ONE, 2012 BackgroundNeural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage.
Barbara Murdoch +2 more
doaj +1 more source
A novel role for Lh3 dependent ECM modifications during neural crest cell migration in zebrafish. [PDF]
PLoS ONE, 2013 During vertebrate development, trunk neural crest cells delaminate along the entire length of the dorsal neural tube and initially migrate as a non-segmented sheet.
Santanu Banerjee +3 more
doaj +1 more source