Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies. [PDF]
PLoS ONE, 2015 Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue.
Ellen Binder +8 more
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eLife, 2022 Production and emigration of neural crest cells is a transient process followed by the emergence of the definitive roof plate. The mechanisms regulating the end of neural crest ontogeny are poorly understood. Whereas early crest development is stimulated
Dina Rekler, Chaya Kalcheim
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Incremental evolution of the neural crest, neural crest cells and neural crest‐derived skeletal tissues [PDF]
Journal of Anatomy, 2012 AbstractUrochordates (ascidians) have recently supplanted cephalochordates (amphioxus) as the extant sister taxon of vertebrates. Given that urochordates possess migratory cells that have been classified as ‘neural crest‐like’– and that cephalochordates lack such cells – this phylogenetic hypothesis may have significant implications with respect to the
Brian K, Hall, J Andrew, Gillis
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Protein tyrosine phosphatase 4A3 (PTP4A3) is required for Xenopus laevis cranial neural crest migration in vivo. [PDF]
PLoS ONE, 2013 Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and ...
Selma Maacha +7 more
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RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification
eLife, 2022 While neural crest development is known to be transcriptionally controlled via sequential activation of gene regulatory networks (GRNs), recent evidence increasingly implicates a role for post-transcriptional regulation in modulating the output of these ...
Erica J Hutchins +4 more
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Stem Cell Research, 2020 Neural crest cells are an embryonic multipotent stem cell population. Recent studies in model organisms have suggested that neural crest cells are specified earlier than previously thought, at blastula stages.
Maneeshi S. Prasad +3 more
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Xenopus Nkx6.3 is a neural plate border specifier required for neural crest development. [PDF]
PLoS ONE, 2014 In vertebrates, the neural plate border (NPB) is established by a group of transcription factors including Dlx3, Msx1 and Zic1. The crosstalk between these NPB specifiers governs the separation of the NPB region into placode and neural crest (NC ...
Zuming Zhang +5 more
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Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
eLife, 2020 Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness.
Chi Jung Hung +3 more
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Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT
Frontiers in Physiology, 2021 Canonical Wnt signaling plays an essential role in proper craniofacial morphogenesis, at least partially due to regulation of various aspects of cranial neural crest development.
Erica J. Hutchins +2 more
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DNA methyltransferase 3b is dispensable for mouse neural crest development.
PLoS ONE, 2012 The neural crest is a population of multipotent cells that migrates extensively throughout vertebrate embryos to form diverse structures. Mice mutant for the de novo DNA methyltransferase DNMT3b exhibit defects in two neural crest derivatives, the ...
Bridget T Jacques-Fricke +2 more
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