Results 11 to 20 of about 72,615 (309)
The neural crest and neural crest defects [PDF]
Biomedical Reviews, 2002 The neural crest is a fascinating embryonic tissue for more than one reason. In the adult organism it gives rise to an array of distinct cell types and tissues. It is responsible for many birth defects, familial diseases and malignancies, and it is amenable to the elucidation of mechanisms that regulate stem cell differentiation.
Maya Sieber-Blum, Zhijian Zhang
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Protein tyrosine phosphatase 4A3 (PTP4A3) is required for Xenopus laevis cranial neural crest migration in vivo. [PDF]
PLoS ONE, 2013 Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and ...
Selma Maacha +7 more
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Stem Cell Research, 2020 Neural crest cells are an embryonic multipotent stem cell population. Recent studies in model organisms have suggested that neural crest cells are specified earlier than previously thought, at blastula stages.
Maneeshi S. Prasad +3 more
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Xenopus Nkx6.3 is a neural plate border specifier required for neural crest development. [PDF]
PLoS ONE, 2014 In vertebrates, the neural plate border (NPB) is established by a group of transcription factors including Dlx3, Msx1 and Zic1. The crosstalk between these NPB specifiers governs the separation of the NPB region into placode and neural crest (NC ...
Zuming Zhang +5 more
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RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells [PDF]
, 2023 The availability of nucleotides has a direct impact on transcription. Inhibition of dihydroorate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels.
Santoriello, Cristina +18 more
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Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
eLife, 2020 Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness.
Chi Jung Hung +3 more
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Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT
Frontiers in Physiology, 2021 Canonical Wnt signaling plays an essential role in proper craniofacial morphogenesis, at least partially due to regulation of various aspects of cranial neural crest development.
Erica J. Hutchins +2 more
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Current Biology, 2003 It is generally accepted that the vertebrates evolved from protochordates ancestors, probably from an animal akin to modern day Amphioxus, a sessile filter feeder whose anatomical organisation is in many ways very similar to that of vertebrates. It has a dorsal nerve cord, a notochord, segmented muscle blocks and pharyngeal gill slits, but it lacks ...
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DNA methyltransferase 3b is dispensable for mouse neural crest development.
PLoS ONE, 2012 The neural crest is a population of multipotent cells that migrates extensively throughout vertebrate embryos to form diverse structures. Mice mutant for the de novo DNA methyltransferase DNMT3b exhibit defects in two neural crest derivatives, the ...
Bridget T Jacques-Fricke +2 more
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Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells [PDF]
, 2008 Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves ...
Howard, Beatrice +19 more
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