Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E is an element of 4 status and cerebrospinal fluid amyloid-beta 42 levels [PDF]
, 2014 Introduction: Emerging evidence suggests that decreased adult hippocampal neurogenesis represents an early critical event in the course of Alzheimer's disease (AD).
Annas, Peter +14 more
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Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus.
Frontiers in Neuroscience, 2013 Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. Although inducible-reversible transgenic mouse models are increasingly being used to investigate adult
Sebastien eSultan +2 more
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Adult Neurogenesis Workshop report [PDF]
Frontiers in Neuroscience, 2010 The workshop was held on July 3, 2009, at the University of Toronto, Canada, and provided a forum for researchers in the field of adult neurogenesis to learn about recent progress in the field, and to present and discuss their ongoing research. The program included talks by mostly local trainees and faculty from the field of adult neurogenesis, who ...
Rosenzweig, Shira, Luu, Paul
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Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis [PDF]
, 2005 In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus.
Wallinga, Alinde E., +10 more
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Role of adult hippocampal neurogenesis in stress resilience
Neurobiology of Stress, 2015 There is a growing appreciation that adult hippocampal neurogenesis plays a role in emotional and cognitive processes related to psychiatric disorders. Although many studies have investigated the effects of stress on adult hippocampal neurogenesis, most ...
Brunno R. Levone +2 more
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Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]
, 2013 Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Parthsarathy, Vadivel +1 more
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Genetic Methods to Identify and Manipulate Newly born Neurons in the Adult Brain
Frontiers in Neuroscience, 2011 Although mammalian neurogenesis is mostly completed by the perinatal period, new neurons are continuously generated in the subventricular zone of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus.
Itaru eImayoshi +2 more
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Targeting Adult Neurogenesis for Brain Recovery After Stroke: The Next Frontier in Stroke Medicine
, 2022 One in four people over age 25 will have a stroke in their lifetime. Globally, an estimated 80 million people are currently living with stroke with many experiencing chronic disability and unmet needs.
Ong, Lin Kooi +4 more
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Neurogenesis in the Adult Brain [PDF]
The Journal of Neuroscience, 2002 A milestone is marked in our understanding of the brain with the recent acceptance, contrary to early dogma, that the adult nervous system can generate new neurons. One could wonder how this dogma originally came about, particularly because all organisms have some cells that continue to divide,
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Frontiers in Neuroscience, 2018 Streptozotocin (STZ)-induced diabetes impairs learning and memory performance and reduces adult hippocampal neurogenesis. Physical exercise brings beneficial effects.
Suk-Yu Yau +8 more
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