Adult neurogenesis in natural populations [PDF]
, 2001 The dogma that the adult brain produces no new neurons has been overturned, but the critics are still asking, so what? Is adult neurogenesis a biologically relevant phenomenon, or is it perhaps harmful because it disrupts the existing neuronal circuitry?
L Galea +3 more
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Engineering of Adult Neurogenesis and Gliogenesis [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Neural stem/progenitor cells (NSPCs) retain their ability to generate newborn neurons throughout life in the mammalian brain. Here, we describe how recently developed virus- and transgenesis-based techniques will help us (1) to understand the functional effects of neurogenesis in health and disease, (2) to design novel approaches to harness the ...
Berninger, Benedikt +1 more
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Heavy metals and adult neurogenesis
Current Opinion in Toxicology, 2021 With extensive use in industrial and agriculture applications, overexposure to heavy metals has become a global public health concern. The nervous system is vulnerable to many heavy metals, including cadmium, lead, and mercury. However, the knowledge about the underlying mechanisms of these metals' neurotoxicity is still very limited.
Hao Wang, Megumi T. Matsushita
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Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E is an element of 4 status and cerebrospinal fluid amyloid-beta 42 levels [PDF]
, 2014 Introduction: Emerging evidence suggests that decreased adult hippocampal neurogenesis represents an early critical event in the course of Alzheimer's disease (AD).
Annas, Peter +14 more
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Development of the adult neurogenic niche in the hippocampus of mice
Frontiers in Neuroanatomy, 2015 When does adult hippocampal neurogenesis begin? We describe the development of the neurogenic niche in the subgranular zone (SGZ) of the hippocampal dentate gyrus. We did so from the perspective of the situation in the adult.Ontogeny of the dentate gyrus
Zeina eNicola +2 more
doaj +1 more source
Effects of amphetamine administration on neurogenesis in adult rats
, 2017 In our study expression of phospho-(Ser-10)-histone H3 (pH3S10), a marker for the early stage of neurogenesis, and cellular early response genes were investigated using c-Fos protein as an example of a transcription factor in the neurogenic process in ...
Tomasz Stępień +4 more
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P2X7 receptor signaling during adult hippocampal neurogenesis [PDF]
, 2019 Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus. Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.
Lovelace, Michael +16 more
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Beclin1 Regulates Adult Hippocampal Neurogenesis [PDF]
, 2015 Adult neurogenesis is a process that produces neurons in the adult brain and garners potential for the development of novel therapeutic interventions to combat neurodegenerative and other brain related diseases.
Vaculik, Michael
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Adult Hippocampal Neurogenesis: A Possible Way how Physical Exercise Counteracts Stress
Cell Transplantation, 2011 It was considered that neurogenesis only occurred during the embryonic and developmental stage. This view has greatly changed since the discovery of adult neurogenesis in two brain regions: the hippocampus and the olfactory bulb.
Suk-Yu Yau +2 more
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Regulation of neurogenesis by neurotrophins during adulthood: expected and unexpected roles
Frontiers in Neuroscience, 2016 The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in
Marçal eVilar, Helena eMira
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