Results 41 to 50 of about 1,598,089 (284)
Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]
, 2006 The etiology of Alzheimer’s disease (AD) remains a great challenge for neurological research. Extensive investigations for almost one hundred years have led to profound insights of the pathological and molecular mechanisms that affect the AD brain, and
Ermini, Florian V.
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Strength exercise weakens aerobic exercise-induced cognitive improvements in rats. [PDF]
PLoS ONE, 2018 Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown.
Yongsheng Lan +7 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Neural Regeneration ResearchHippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease. Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.
Mackenzie M. Spicer +7 more
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What do we know about adult mammalian hippocampal neurogenesis so far? [PDF]
Medicinski PodmladakIt is known that the adult mammalian brain can add new neurons throughout the whole lifespan. Neural stem cells reside in the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the rostral lateral ventricle.
Jeremić Rada +2 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Effect of Exercise on Adult Neurogenesis in Crayfish [PDF]
, 2012 Adult neurogenesis, formation of new neurons, has been determined to be a part of the normal physiology in all species of animals studied to date. There have been several factors observed to increase the number of newly formed cells; the most potent of ...
Klutts, Jennifer E.
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Neural Regeneration ResearchAdult hippocampal neurogenesis is linked to memory formation in the adult brain, with new neurons in the hippocampus exhibiting greater plasticity during their immature stages compared to mature neurons. Abnormal adult hippocampal neurogenesis is closely
Ye Liu +3 more
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FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
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Neurogenesis and astrogenesis contribute to vestibular compensation in the neurectomized adult cat: cellular and behavioral evidence [PDF]
, 2009 Neurogenesis occurs in some regions of the adult mammalian brain and gives rise to neurons integrated into functional networks. In pathological or postlesional conditions, neurogenesis and astrogenesis can also occur, as demonstrated in the deafferented ...
Jean Michel Brezun +4 more
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