Results 61 to 70 of about 1,598,089 (284)

P2X7 receptor signaling during adult hippocampal neurogenesis [PDF]

, 2019
Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus. Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.
Lovelace, Michael, Leeson, Hannah, Chan-Ling, Tailoi, Leeson, H, Leeson, Hannah C, Weible, Michael, Brownlie, Jeremy C, Gu, Ben J, Lovelace, Michael D, Gu, Ben, Chan-Ling, T, Weible, Michael W, Brownlie, J, Brownlie, Jeremy, Lovelace, M ; https://orcid.org/, Weible, M, Gu, B   +16 more
core   +1 more source

Development of the adult neurogenic niche in the hippocampus of mice

Frontiers in Neuroanatomy, 2015
When does adult hippocampal neurogenesis begin? We describe the development of the neurogenic niche in the subgranular zone (SGZ) of the hippocampal dentate gyrus. We did so from the perspective of the situation in the adult.Ontogeny of the dentate gyrus
Zeina eNicola, Klaus eFabel, Gerd eKempermann   +2 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Engineering of Adult Neurogenesis and Gliogenesis [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Neural stem/progenitor cells (NSPCs) retain their ability to generate newborn neurons throughout life in the mammalian brain. Here, we describe how recently developed virus- and transgenesis-based techniques will help us (1) to understand the functional effects of neurogenesis in health and disease, (2) to design novel approaches to harness the ...
Berninger, Benedikt, Jessberger, Sebastian   +1 more
openaire   +4 more sources

Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases

, 2016
Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood.
Ni Song, He Liu
core   +1 more source

Adult Neurogenesis

Cell Stem Cell
Abstract Adult neurogenesis—the development of new neurons under the conditions of the adult brain—is an exception, not the rule, but we know today that the new neurons contribute to key brain functions. This particularly applies to neurogenesis in the hippocampus of adult mammals, including rodents and humans, where adult ...
Doludda, Birte, Barde, Warsha, D’Egidio, Francesco, Fitzsimons, Carlos P., Frisén, Jonas, Gage, Fred H., Jessberger, Sebastian, Lazarov, Orly, Lie, D. Chichung, Lucassen, Paul J., de Lucia, Chiara; id_orcid 0000-0002-7541-2814, Salta, Evgenia, Song, Hongjun, Song, Juan, Thuret, Sandrine; id_orcid 0000-0003-1260-8083, Toda, Tomohisa, Kempermann, Gerd   +16 more
  +7 more sources

Regulation of neurogenesis by neurotrophins during adulthood: expected and unexpected roles

Frontiers in Neuroscience, 2016
The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in
Marçal eVilar, Helena eMira
doaj   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Epigenetic aging in adult neurogenesis

Hippocampus, 2023
AbstractNeural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age‐related impairments in NSC activity underlie this reduction.
Zocher, Sara, Toda, Tomohisa
openaire   +4 more sources

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source