Results 81 to 90 of about 1,664,491 (187)
Finding the Roots of Adult Neurogenesis [PDF]
Cell, 2015 In select areas of the brain, neural stem cells produce new neurons throughout life. An elegant new study in this issue of Cell reveals the origins of a stem cell population that persists into adulthood and uncovers a surprising relationship between neurons born in the mature brain and those generated early in development.
openaire +4 more sources
Nitric oxide regulation of adult neurogenesis
, 2014 The ubiquitous gaseous signaling molecule nitric oxide participates in the regulation of a variety of physiological and pathological processes, including adult neurogenesis.
Angela Cheung +3 more
core +1 more source
Depression and adult hippocampal neurogenesis
Folia Pharmacologica Japonica, 2010 現在，うつ病の治療薬はセロトニンやノルアドレナリンといったモノアミンを増加させる薬剤が中心として用いられているが，脳内の細胞外モノアミン濃度は抗うつ薬の投与数時間後には増加するのに対し，臨床における治療効果発現までには数週間の慢性投与が必要とされることもあり，抗うつ薬の治療発現メカニズムは未だ明らかとされていない．近年，成熟期の脳においても海馬歯状回といった特定領域において，神経幹・前駆細胞が存在し，神経細胞が新生されることが明らかにされている．この海馬における神経新生は，うつ病発症の危険因子とされるストレスによって抑制され，逆に抗うつ薬を慢性投与することによって促進される．さらに，海馬神経新生を阻害すると，行動薬理評価モデルにおける抗うつ薬の作用が消失するなどの報告から ...
Masuda, Takahiro +2 more
openaire +3 more sources
Regulation of Adult Neurogenesis in Mammalian Brain
, 2020 Adult neurogenesis is a multistage process by which neurons are generated and integrated into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two specialized niches, the subgranular zone (SGZ) of the dentate gyrus and ...
Gerry Melino +7 more
core +1 more source
, 2013 Exposure to exercise increases the generation of new neurons in the adult neurogenesis. However, only few studies have investigated the beneficial effect of physical exercise in impaired neurogenesis paradigms.
Mattera A +5 more
core
Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis [PDF]
Adult neurogenesis is restricted to two distinct areas of the mammalian brain: the olfactory bulb (OB) and the dentate gyrus (DG). Despite its spatial restriction, adult neurogenesis is of crucial importance for sensory processing and learning and memory.
Götz, Magdalena +7 more
core
Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells [PDF]
, 2005 The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or ...
Hack, M.A., Hack, Michael Anton
core +1 more source
Neurogenesis and apoptosis in the developmentally regulated loss of spinal cord regeneration. [PDF]
, 2006 Unlike the adult mammal, the chick can successfully regenerate its spinal cord until embryonic day (E) 13. Multiple factors may contribute to the subsequent loss of regenerative capacity, although most research has concentrated on axonal re-growth ...
Whalley, K.A., Whalley, Katherine Ann
core
APIK Journal of Internal MedicineAdult neurogenesis, the generation of new neurons within the mature brain, remains an active area of investigation and debate. Robust evidence from animal models demonstrates that newly generated neurons contribute to learning, memory, and neural ...
Oluwaseye Emmanuel Olayemi +3 more
doaj +1 more source