Results 71 to 80 of about 1,598,089 (284)

Adult Hippocampal Neurogenesis: A Possible Way how Physical Exercise Counteracts Stress

Cell Transplantation, 2011
It was considered that neurogenesis only occurred during the embryonic and developmental stage. This view has greatly changed since the discovery of adult neurogenesis in two brain regions: the hippocampus and the olfactory bulb.
Suk-Yu Yau, Benson Wui-Man Lau, Kwok-Fai So   +2 more
doaj   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Effects of postsynaptic serotonin1A receptors on adult neurogenesis

, 2016
Abkürzungsverzeichnis IV Abbildungs- und Tabellenverzeichnis VI 1 EINLEITUNG 1 2 LITERATURÜBERSICHT 3 2.1 Adulte Neurogenese/Gliogenese 3 2.1.1 Neurogenese 3 2.1.1.1 Adulte Neurogenese 3 Stammzellen im adulten ZNS 5 Adulte Neurogenese im Bulbus ...
Noto, Bettina
core   +1 more source

Reproduction: A New Venue for Studying Function of Adult Neurogenesis?

Cell Transplantation, 2011
Adult neurogenesis has been a focus within the past few years because it is a newly recognized form of neuroplasticity that may play significant roles in behaviors and recovery process after disease.
Benson Wui-Man Lau, Suk-Yu Yau, Kwok-Fai So   +2 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

BDNF Haploinsufficiency Limits Voluntary Exercise-Induced Adult Hippocampal Neurogenesis

Biology
Adult hippocampal neurogenesis is involved in hippocampal plasticity and can be enhanced by voluntary physical activity, which also elevates “brain-derived neurotrophic factor” (BDNF) levels and improves memory performance. BDNF might either be essential
Monique Klausch, Jens Schepers, Viola von Bohlen und Halbach, Oliver von Bohlen und Halbach   +3 more
doaj   +1 more source

The Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis

Brain Sciences, 2019
Adult neurogenesis—the formation and functional integration of adult-generated neurons—remains a hot neuroscience topic. Decades of research have identified numerous endogenous (such as neurotransmitters and hormones) and exogenous (such as ...
Claudia Jorgensen, James Taylor, Tyler Barton   +2 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

The maternal brain: an organ with peripartal plasticity. [PDF]

, 2014
The time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been ...
Aigner, Ludwig, Fischer, Thorsten, Volker Rudolf Jacobs, Jacobs, Volker Rudolf, Ludwig Aigner, Hillerer, Katharina Maria, Katharina Maria Hillerer, Thorsten Fischer   +7 more
core   +1 more source

Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells [PDF]

, 2005
The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or ...
Hack, M.A., Hack, Michael Anton
core   +1 more source