Results 111 to 120 of about 110,453 (370)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory

Molecular Brain, 2009
Newborn neurons in the subgranular zone (SGZ) of the hippocampus incorporate into the dentate gyrus and mature. Numerous studies have focused on hippocampal neurogenesis because of its importance in learning and memory.
Ko Hyoung-Gon, Jang Deok-Jin, Son Junehee, Kwak Chuljung, Choi Jun-Hyeok, Ji Young-Hoon, Lee Yun-Sil, Son Hyeon, Kaang Bong-Kiun   +8 more
doaj   +1 more source

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis

bioRxiv, 2020
Dynamic DNA methylation controls gene-regulatory networks underlying cell fate specification. How DNA methylation patterns change during adult hippocampal neurogenesis and their relevance for adult neural stem cell differentiation and related brain ...
Sara Zocher, R. Overall, G. Berdugo-Vega, N. Rund, A. Karasinsky, Vijay S Adusumilli, Christina Steinhauer, Sina Scheibenstock, K. Händler, J. Schultze, F. Calegari, G. Kempermann   +11 more
semanticscholar   +1 more source

The cell cycle–apoptosis connection revisited in the adult brain [PDF]

, 2005
Adult neurogenesis is studied in vivo using thymidine analogues such as bromodeoxyuridine (BrdU) to label DNA synthesis during the S phase of the cell cycle.
Bauer, Sylvian, Patterson, Paul H.
core   +3 more sources

Functions and Dysfunctions of Adult Hippocampal Neurogenesis [PDF]

Annual Review of Neuroscience, 2014
Adult neurogenesis, a developmental process of generating functionally integrated neurons, occurs throughout life in the hippocampus of the mammalian brain and showcases the highly plastic nature of the mature central nervous system. Significant progress has been made in recent years to decipher how adult neurogenesis contributes to brain functions ...
Kimberly M, Christian, Hongjun, Song, Guo-li, Ming   +2 more
openaire   +2 more sources

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

The role of microglia in adult hippocampus neurogenesis

Frontiers in Cellular Neuroscience, 2013
Our view of microglia has dramatically changed in the last decade. From cells being silent in the healthy brain, microglia have emerged to be actively involved in several brain physiological functions, including adult hippocampal neurogenesis, cognitive
Carmelina eGemma, Adam D Bachstetter
doaj   +1 more source

Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression [PDF]

, 2013
Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been
A Bedard, A Benraiss, A Caspi, A Kowalczyk, A Mateus-Pinheiro, A Mateus-Pinheiro, A Reif, A Sahay, A Surget, A Vidal, AG Dayer, AH Kim, António Mateus-Pinheiro, B Artegiani, B Seri, B Vollmayr, B Winner, C Ernst, C Ma, C Zhao, CD Fowler, CD Fowler, CJ Sherr, CJ Sherr, CL Frank, CM Cooper-Kuhn, CM Pariante, CY Kuan, D Cobrinik, D Ehninger, DC Lie, DJ David, DN Abrous, DT Balu, DZ Liu, E Bruel-Jungerman, E Gould, E Sicinska, EJ Nestler, F Calegari, F Calegari, F Doetsch, G Kempermann, G Kronenberg, GR Heninger, GU Hoglinger, H Mira, H Praag van, H Suh, J Brown, J Qiu, J Qiu, JB Aimone, JE Malberg, JJ Breunig, JM Bessa, JP Lopes, JS Snyder, JS Snyder, K Herrup, K Herrup, K Lai, K Pham, K Yoshikawa, K Yoshimi, KA Cunningham, KP Lesch, KT Gobeske, L Borghese, L Goncalves, L Santarelli, Luísa Pinto, M Biebl, M Carlen, M Kleber, M Kodama, M Malumbres, M Papp, M Zhao, MD Brandt, ME Legrier, ME Legrier, ML Wong, MS Nokia, MV Kokoeva, N Hanoun, N Tsankova, Nuno Sousa, O Berton, O Berton, O von Bohlen und Halbach, P Beukelaers, P Salomoni, P Sicinski, Patrícia Patrício, PJ Bernier, PJ Clark, PJ Lucassen, PR Zoladz, R Vandenbosch, RJ Schloesser, RL Zhang, RL Zhang, RN Pechnick, RN Pechnick, S Giovanni Di, S Jessberger, S Jessberger, S Kasper, S Lee, S Lugert, S Schmetsdorf, S Soriano, SB Glickstein, SB Pinnock, SG Disner, SJ Morrison, T Kuwabara, T Miyata, TJ Shors, TJ Shors, U Galderisi, V Chesnokova, V Khurana, V Krishnan, V Lemaire, VM Heine, W Deng, W Ye, WL Zhu, Y Fan, Y Gu, Y Mu, Z Lu   +133 more
core   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

The Role of Smad2 in Adult Neuroplasticity as Seen through Hippocampal-Dependent Spatial Learning/Memory and Neurogenesis [PDF]

, 2021
Simona Gradari, Antonio Herrera, Patricia Tezanos, Ángela Fontán‐Lozano, Sebastián Pons, José Luís Trejo   +5 more
openalex   +1 more source