Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health
Frontiers in Neural Circuits, 2017 The process of neurogenesis has been demonstrated to occur throughout life in the subgranular zone (SGZ) of the hippocampal dentate gyrus of several mammals, including humans.
Cristina Navarro-Sanchis +3 more
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Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. [PDF]
PLoS ONE, 2015 Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in ...
Jacqueline A Bonds +6 more
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Stem Cell Reports, 2016 Adult hippocampal neurogenesis was impaired in several Alzheimer's disease models overexpressing mutant human amyloid precursor protein (hAPP). However, the effects of wild-type hAPP on adult neurogenesis and whether the impaired adult hippocampal ...
Hongyu Pan +12 more
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Mini review: The relationship between energy status and adult hippocampal neurogenesis
Neuroscience Letters, 2021 The ability to generate new hippocampal neurons throughout adulthood and successfully integrate them into existing neural networks is critical to cognitive function, while disordered regulation of this process results in neurodegenerative or psychiatric ...
Taylor Landry, Hu Huang
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Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory [PDF]
, 2011 Integration of new neurons into the adult hippocampus has been linked to specific types of learning. Primary cilia were found to be required for the formation of adult neural stem cells (NSCs) in the hippocampal dentate gyrus during development. However,
Amador-Arjona, A. +7 more
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Molecular Psychiatry, 2021 Hippocampal adult neurogenesis has been associated to many cognitive, emotional, and behavioral functions and dysfunctions, and its status as a selected effect or an “appendix of the brain” has been debated.
D. Abrous, M. Koehl, M. Lemoine
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Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis [PDF]
, 2005 In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus.
Borght, Karin van der, +4 more
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]
, 2020 Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B. +11 more
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PLoS Computational Biology, 2022 Exposures to a hypomagnetic field can affect biological processes. Recently, it has been observed that hypomagnetic field exposure can adversely affect adult hippocampal neurogenesis and hippocampus-dependent cognition in mice.
Rishabh Rishabh +3 more
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Adult Neurogenesis and Dendritic Remodeling in Hippocampal Plasticity: Which One is more Important?
Cell Transplantation, 2014 Accumulating knowledge has shown that a decrease in hippocampal neurogenesis is linked to the pathophysiology of mood disorders and some hippocampal-dependent learning and memory tasks.
Suk-Yu Yau, Kwok-Fai So
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