Results 31 to 40 of about 39,669 (209)

Depression and adult hippocampal neurogenesis

Folia Pharmacologica Japonica, 2010
現在，うつ病の治療薬はセロトニンやノルアドレナリンといったモノアミンを増加させる薬剤が中心として用いられているが，脳内の細胞外モノアミン濃度は抗うつ薬の投与数時間後には増加するのに対し，臨床における治療効果発現までには数週間の慢性投与が必要とされることもあり，抗うつ薬の治療発現メカニズムは未だ明らかとされていない．近年，成熟期の脳においても海馬歯状回といった特定領域において，神経幹・前駆細胞が存在し，神経細胞が新生されることが明らかにされている．この海馬における神経新生は，うつ病発症の危険因子とされるストレスによって抑制され，逆に抗うつ薬を慢性投与することによって促進される．さらに，海馬神経新生を阻害すると，行動薬理評価モデルにおける抗うつ薬の作用が消失するなどの報告から ...
Masuda, Takahiro, Nakagawa, Shin, Koyama, Tsukasa   +2 more
openaire   +3 more sources

Role of adult hippocampal neurogenesis in stress resilience

Neurobiology of Stress, 2015
There is a growing appreciation that adult hippocampal neurogenesis plays a role in emotional and cognitive processes related to psychiatric disorders. Although many studies have investigated the effects of stress on adult hippocampal neurogenesis, most ...
Brunno R. Levone, John F. Cryan, Olivia F. O'Leary   +2 more
doaj   +1 more source

The Effects of Anesthesia on Adult Hippocampal Neurogenesis [PDF]

Frontiers in Neuroscience, 2020
In animal studies, prolonged sedation with general anesthetics has resulted in cognitive impairments that can last for days to weeks after exposure. One mechanism by which anesthesia may impair cognition is by decreasing adult hippocampal neurogenesis. Several studies have seen a reduction in cell survival after anesthesia in rodents with most studies ...
Jenny L. Kim, Nicholas E. Bulthuis, Heather A. Cameron   +2 more
openaire   +3 more sources

Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult Hippocampal Neurogenesis

Frontiers in Cellular Neuroscience, 2018
In mammalian species, including humans, the hippocampal dentate gyrus (DG) is a primary region of adult neurogenesis. Aberrant adult hippocampal neurogenesis is associated with neurological pathologies.
Jennifer Stefani, Olga Tschesnokowa, Marta Parrilla, Marta Parrilla, Bernard Robaye, Jean-Marie Boeynaems, Amparo Acker-Palmer, Amparo Acker-Palmer, Amparo Acker-Palmer, Herbert Zimmermann, Kristine Gampe   +10 more
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Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health

Frontiers in Neural Circuits, 2017
The process of neurogenesis has been demonstrated to occur throughout life in the subgranular zone (SGZ) of the hippocampal dentate gyrus of several mammals, including humans.
Cristina Navarro-Sanchis, Olivier Brock, Raphaelle Winsky-Sommerer, Sandrine Thuret   +3 more
doaj   +1 more source

Impact of diet on adult hippocampal neurogenesis [PDF]

Genes & Nutrition, 2009
Research over the last 5 years has firmly established that learning and memory abilities, as well as mood, can be influenced by diet, although the mechanisms by which diet modulates mental health are not well understood. One of the brain structures associated with learning and memory, as well as mood, is the hippocampus.
Stangl, Doris, Thuret, Sandrine
openaire   +3 more sources

Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein

Stem Cell Reports, 2016
Adult hippocampal neurogenesis was impaired in several Alzheimer's disease models overexpressing mutant human amyloid precursor protein (hAPP). However, the effects of wild-type hAPP on adult neurogenesis and whether the impaired adult hippocampal ...
Hongyu Pan, Dongpi Wang, Xiaoqin Zhang, Dongming Zhou, Heng Zhang, Qi Qian, Xiao He, Zhaoling Liu, Yunjin Liu, Tingting Zheng, Ling Zhang, Mingkai Wang, Binggui Sun   +12 more
doaj   +1 more source

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. [PDF]

PLoS ONE, 2015
Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in ...
Jacqueline A Bonds, Yafit Kuttner-Hirshler, Nancy Bartolotti, Matthew K Tobin, Michael Pizzi, Robert Marr, Orly Lazarov   +6 more
doaj   +1 more source

Functions and Dysfunctions of Adult Hippocampal Neurogenesis [PDF]

Annual Review of Neuroscience, 2014
Adult neurogenesis, a developmental process of generating functionally integrated neurons, occurs throughout life in the hippocampus of the mammalian brain and showcases the highly plastic nature of the mature central nervous system. Significant progress has been made in recent years to decipher how adult neurogenesis contributes to brain functions ...
Kimberly M, Christian, Hongjun, Song, Guo-li, Ming   +2 more
openaire   +2 more sources

Radical pairs may explain reactive oxygen species-mediated effects of hypomagnetic field on neurogenesis.

PLoS Computational Biology, 2022
Exposures to a hypomagnetic field can affect biological processes. Recently, it has been observed that hypomagnetic field exposure can adversely affect adult hippocampal neurogenesis and hippocampus-dependent cognition in mice.
Rishabh Rishabh, Hadi Zadeh-Haghighi, Dennis Salahub, Christoph Simon   +3 more
doaj   +1 more source