Results 21 to 30 of about 39,669 (209)
IBRO Neuroscience Reports, 2022 Norepinephrine (NE), and specific adrenoceptors, have been reported to influence distinct aspects of adult hippocampal neurogenesis, including latent stem cell activation, progenitor proliferation, and differentiation.
Darshana Kapri +9 more
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Dynamics of Hippocampal Neurogenesis in Adult Humans [PDF]
Cell, 2013 Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb ...
Spalding, Kirsty L +13 more
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Unraveling human adult hippocampal neurogenesis [PDF]
Nature Protocols, 2020 Adult neurogenesis occurs in a few selected regions of the mammalian brain. One such region is the hippocampus, the so-called gateway to memory, where adult hippocampal neurogenesis (AHN) occurs. Here, we provide a comprehensive description of the methods used in our laboratory to unambiguously detect a population of immature neurons in the human ...
Miguel Flor-García +5 more
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HDAC1 Regulates Neuronal Differentiation
Frontiers in Molecular Neuroscience, 2022 In adult hippocampal neurogenesis, chromatin modification plays an important role in neural stem cell self-renewal and differentiation by regulating the expression of multiple genes. Histone deacetylases (HDACs), which remove acetyl groups from histones,
Vanesa Nieto-Estevez +12 more
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A new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease
Neural Regeneration Research, 2022 Several lines of evidence have established that proliferation and differentiation of neural stem cells into neurons within the sub-granular zone of the dentate gyrus, a process named adult hippocampal neurogenesis, contribute to maintaining healthy ...
Maya A Hanspal, Sébastien Gillotin
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Frontiers in Molecular Neuroscience, 2021 Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD).
Domenica Donatella Li Puma +5 more
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Cells, 2023 Central nervous system infections caused by pathogens crossing the blood–brain barrier are extremely damaging and trigger cellular alterations and neuroinflammation.
Katerina Segklia +2 more
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Modification of hippocampal circuitry by adult neurogenesis [PDF]
Developmental Neurobiology, 2012 AbstractThe adult hippocampus is one of the primary neural structures involved in memory formation. In addition to synapse‐specific modifications thought to encode information at the subcellular level, changes in the intrahippocampal neuro‐populational activity and dynamics at the circuit‐level may contribute substantively to the functional capacity of
Juan, Song +3 more
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Cdk5 is essential for adult hippocampal neurogenesis [PDF]
Proceedings of the National Academy of Sciences, 2008 The molecular factors regulating adult neurogenesis must be understood to harness the therapeutic potential of neuronal stem cells. Although cyclin-dependent kinase 5 (Cdk5) plays a critical role in embryonic corticogenesis, its function in adult neurogenesis is unknown. Here, we assessed the role of Cdk5 in the generation of dentate gyrus (DG) granule
Diane C, Lagace +6 more
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Frontiers in Neuroscience, 2018 Streptozotocin (STZ)-induced diabetes impairs learning and memory performance and reduces adult hippocampal neurogenesis. Physical exercise brings beneficial effects.
Suk-Yu Yau +8 more
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