Results 71 to 80 of about 110,453 (370)
Modulation of adult-born neurons in the inflamed hippocampus. [PDF]
, 2013 Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core +2 more sources
Adult hippocampal neurogenesis in Alzheimer's disease
, 2021 New neurons are generated in the dentate gyrus of the adult brain throughout life. They incorporate in the granular cell layer of the dentate gyrus and integrate in the hippocampal circuitry. Increasing evidence suggests that new neurons play a role in learning and memory.
Ahmed, Disouky, Orly, Lazarov
openaire +3 more sources
Dynamics of Hippocampal Neurogenesis in Adult Humans [PDF]
Cell, 2013 Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb ...
Spalding, Kirsty L +13 more
openaire +4 more sources
Neural Regeneration ResearchHippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease. Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.
Mackenzie M. Spicer +7 more
doaj +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability [PDF]
, 2017 Oligophrenin-1 (OPHN1) is a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID). How loss of function of Ophnl affects neuronal development is only partly understood.
Allegra, M +7 more
core +1 more source
Neural Regeneration ResearchAdult hippocampal neurogenesis is linked to memory formation in the adult brain, with new neurons in the hippocampus exhibiting greater plasticity during their immature stages compared to mature neurons. Abnormal adult hippocampal neurogenesis is closely
Ye Liu +3 more
doaj +1 more source
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]
, 2011 Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María +4 more
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Wnt signaling in the regulation of adult hippocampal neurogenesis
Frontiers in Cellular Neuroscience, 2013 In the adult brain new neurons are continuously generated mainly in two regions, the subventricular zone of the lateral ventricles and the subgranular zone (SGZ) in the hippocampal dentate gyrus.
Lorena eVarela-Nallar +1 more
doaj +1 more source
Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal Neurogenesis
Cells, 2022 Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulates adult
Martina Sassi +2 more
doaj +1 more source