Results 1 to 10 of about 407,994 (322)
Hematology Reports, 2021 For patients with Hodgkin Lymphoma (HL) who experience relapse post allogeneic stem cell transplantation, limited treatment options exist, and the ultimate outcome is poor.
Panayotis Kaloyannidis +4 more
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Regulation of stem cell dynamics through volume exclusion [PDF]
Garc\'ia-Tejera R, SchumacherL, Grima R. 2022 Regulation of stem
cell dynamics through volume exclusion. Proc.R.Soc.A478: 20220376, 2022 Maintenance and regeneration of adult tissues rely on the self-renewal of stem cells. Regeneration without over-proliferation requires precise regulation of the stem cell proliferation and differentiation rates. The nature of such regulatory mechanisms in different tissues, and how to incorporate them in models of stem cell population dynamics, is ...
arxiv +1 more source
Establishing a 3D In Vitro Hepatic Model Mimicking Physiologically Relevant to In Vivo State
Cells, 2021 Three-dimensional (3D) bioprinting is a promising technology to establish a 3D in vitro hepatic model that holds great potential in toxicological evaluation.
Hyun Kyoung Kang +10 more
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Nature Communications, 2020 In mammalian cell lines, Cep55 protein recruits the endosomal sorting complex required for transport (ESCRT) and promotes the completion of cell division.
Antonio Tedeschi +5 more
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Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease
Cell Death Discovery, 2022 Mitochondrial dysfunction is associated with familial Alzheimer’s disease (fAD), and the accumulation of damaged mitochondria has been reported as an initial symptom that further contributes to disease progression.
Seung-Eun Lee +8 more
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Modeling adult skeletal stem cell response to laser-machined topographies through deep learning [PDF]
Tissue and Cell: Volume 67, December 2020, 101442, 2020 The response of adult human bone marrow stromal stem cells to surface topographies generated through femtosecond laser machining can be predicted by a deep neural network. The network is capable of predicting cell response to a statistically significant level, including positioning predictions with a probability P < 0.001, and therefore can be used as ...
arxiv +1 more source
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
Nature Communications, 2021 The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its ...
Omar M. Khan +8 more
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Hematology, Transfusion and Cell Therapy, 2022 Objective: Multiple myeloma (MM) is considered a disease of elderlies however, 35-40% of newly diagnosed MM (NDMM) patients (pts) are ≤60 years (ys) old.
Panayotis Kaloyannidis +6 more
doaj
Zika virus infection accelerates Alzheimer’s disease phenotypes in brain organoids
Cell Death Discovery, 2022 Alzheimer’s disease (AD) is one of the progressive neurodegenerative diseases characterized by β-amyloid (Aβ) production and Phosphorylated-Tau (p-Tau) protein in the cerebral cortex. The precise mechanisms of the cause, responsible for disease pathology
Seung-Eun Lee +9 more
doaj +1 more source
Experimental and Molecular Medicine, 2018 Stem cell therapy: Finding the best cells Stem cells from some donors have a stronger therapeutic effect than others, and can be identified by genetic markers.
Insung Kang +12 more
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