Results 91 to 100 of about 797,049 (362)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]

, 2016
Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa, Bonfanti, Paola, Heimberg, Harry, Heremans, Yves, Leuckx, Gunter, Marazzi, Giovanna, Sassoon, David, Sojoodi, Mozhdeh, Staels, Willem, Stradiot, Leslie, Tanaka, Karo, Van de Casteele, Mark   +11 more
core   +3 more sources

Stem cell aging in adult progeria

Cell Regeneration, 2015
Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research ...
Hoi-Hung Cheung, Duanqing Pei, Wai-Yee Chan   +2 more
openaire   +4 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

In search of adult renal stem cells [PDF]

Journal of Cellular and Molecular Medicine, 2004
AbstractThe therapeutic potential of adult stem cells in the treatment of chronic degenerative diseases has becoming increasingly evident over the last few years. Significant attention is currently being paid to the development of novel treatments for acute and chronic kidney diseases too.
ANGLANI, FRANCA, FORINO M, DEL PRETE, DORELLA, TOSETTO, ENRICA, TORREGROSSA R., D'ANGELO, ANGELA   +5 more
openaire   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Developmental toxicity of embryonic 1-naphthol exposure in zebrafish

Di-san junyi daxue xuebao, 2019
Objective To investigate the toxic effects of embryonic exposure to 1-naphthol (1-NAP) on zebrafish development and explore the possible mechanism. Methods Fertilized zebrafish eggs were exposed to 1-NAP at the concentrations of 40, 80, 160 and 200 μmol ...
REN Pingping, REN Pingping, SHU Liping, WANG Yihui, WANG Yihui   +4 more
doaj   +1 more source

Influence of gut microbiome on multiple myeloma: friend or foe?

Journal for ImmunoTherapy of Cancer, 2020
Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, which typically evolves over time from its precursor, monoclonal gammopathy of undetermined significance.
Marcos de Lima, Nausheen Ahmed, Mahmoud Ghannoum, Molly Gallogly, Ehsan Malek   +4 more
doaj   +1 more source

Dietary Regulation of Adult Stem Cells [PDF]

Current Stem Cell Reports, 2017
Dietary intake is a critical regulator of organismal physiology and health. Tissue homeostasis and regeneration are dependent on adult tissue stem cells that self-renew and differentiate into the specialized cell types. As stem cells respond to cues from their environment, dietary signals and nutrients influence tissue biology by altering the function ...
Mana, Miyeko, Kuo, Elaine Yih-Shuen, Yilmaz, Omer   +2 more
openaire   +5 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source