Results 101 to 110 of about 751,739 (361)
Adult neural stem cell plasticity
Neural Regeneration Research, 2019 Stem cells derived from adult tissues have long been considered multipotent, able to differentiate into a limited number of cell types found in their tissue of origin. Embryonic stem cells, in contrast, are pluripotent, which may differentiate into almost all cell types.
Sandquist, Elizabeth, Sakaguchi, Donald
openaire +5 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons? [PDF]
, 2013 Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the ...
Liao, S, Tse, HF
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Stem Cells International, 2020 Previous studies have demonstrated that myocardin-related transcription factor A (MRTF-A) generates a link between the dynamics of the actin cytoskeleton and gene expression with its coregulator, serum response factor (SRF).
Laura Hyväri +4 more
doaj +1 more source
Future Implementation of Adult Stem Cell Therapy in the Current Standards of Care for Myocardial Infarction [PDF]
, 2008 Purpose: Adult stem cells are among the new methods of approaching the treatment of myocardial tissue damage. The purpose of this review is to clarify misconceptions about stem cell therapy efficacy in clinical trials and provide a thorough understanding
Bates, Paul D.
core +1 more source
Small SSEA-4-positive cells from human ovarian cell cultures: related to embryonic stem cells and germinal lineage? [PDF]
, 2013 Background: It has already been found that very small embyronic-like stem cells (VSELs) are present in adult human tissues and organs. The aim of this study was to find if there exists any similar population of cells in cell cultures of reproductive ...
Cvjeticanin, Branko +4 more
core +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Methotrexate-Induced Acute Leukemia: Report of Three Cases and Review of the Literature
Clinical Medicine Insights: Case Reports, 2009 For many years, methotrexate has been used in the treatment of certain chronic medical disorders e.g. rheumatoid arthritis and psoriasis as well as a number of malignant disorders e.g.
Khalid A. Al-Anazi +3 more
doaj +1 more source
Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration. [PDF]
, 2014 Adult mammalian epidermis contains multiple stem cell populations in which quiescent and more proliferative stem and progenitor populations coexist. However, the precise interrelation of these populations in homeostasis remains unclear.
Driskell, Iwona +3 more
core +2 more sources