Results 131 to 140 of about 1,021,356 (297)

IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection

Clinical and Developmental Immunology, 2011
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease.
Robert B. Ashman, Dipti Vijayan, Christine A. Wells   +2 more
doaj   +1 more source

Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase [PDF]

, 2000
Rama K. Jaiswal, Neelam Jaiswal, Scott P. Bruder, Gabriel Mbalaviele, Daniel R. Marshak, Mark F. Pittenger   +5 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus [PDF]

, 2000
Lamya S. Shihabuddin, Philip J. Horner, Jasodhara Ray, Fred H. Gage   +3 more
openalex   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Acinetobacter baumannii Septicemia in a Recipient of an Allogeneic Hematopoietic Stem Cell Transplantation

Case Reports in Transplantation, 2012
Acinetobacter baumannii is a gram-negative, nonfermentative coccobacillus that causes infections in immunocompromised and chronically ill patients and is associated with multidrug resistance.
Khalid Ahmed Al-Anazi, Baha Abdalhamid, Zeyad Alshibani, Khalid Awad, Abdullah Alzayed, Hoda Hassan, Mohammed Alsayiegh   +6 more
doaj   +1 more source

Infectious gastro-enteritis: an uncommon cause of diarrhoea in adult allogeneic and autologous stem cell transplant recipients [PDF]

, 2000
MGJ van Kraaij, AW Dekker, LF Verdonck, AM van Loon, Jan Vinjé, MPG Koopmans, M. Rozenberg-Arska   +6 more
openalex   +1 more source

Searching for adult stem cells in the intestine

EMBO Molecular Medicine, 2009
The epithelium of the small intestine is the most rapidly self‐renewing tissue of mammals. Vigorous proliferation of progenitor cells occurs in crypts, while their differentiated offspring leaves the crypts and travels up the flanks of the villi to suffer death by apoptosis at villus tips 3 days later (Fig 1).
openaire   +4 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans. [PDF]

, 2000
Valéry Gmyr, Julie Kerr–Conte, S Belaïch, B. Vandewalle, Emmanuelle Leteurtre, Marie‐Christine Vantyghem, M Lecomte-Houcke, C Proye, J Lefèbvre, François Pattou   +9 more
openalex   +1 more source