Results 131 to 140 of about 820,702 (356)

Adult stem cell activity in naked mole rats for long-term tissue maintenance. [PDF]

Nat Commun, 2023
Montazid S, Bandyopadhyay S, Hart DW, Gao N, Johnson B, Thrumurthy SG, Penn DJ, Wernisch B, Bansal M, Altrock PM, Rost F, Gazinska P, Ziolkowski P, Hayee B, Liu Y, Han J, Tessitore A, Koth J, Bodmer WF, East JE, Bennett NC, Tomlinson I, Irshad S.   +22 more
europepmc   +2 more sources

Effects of Macromolecular Crowding on Human Adipose Stem Cell Culture in Fetal Bovine Serum, Human Serum, and Defined Xeno-Free/Serum-Free Conditions

Stem Cells International, 2017
Microenvironment plays an important role for stem cell proliferation and differentiation. Macromolecular crowding (MMC) was recently shown to assist stem cells in forming their own matrix microenvironment in vitro.
Mimmi Patrikoski, Michelle Hui Ching Lee, Laura Mäkinen, Xiu Min Ang, Bettina Mannerström, Michael Raghunath, Susanna Miettinen   +6 more
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome [PDF]

, 2017
Michael Slade, John F. DiPersio, Peter Westervelt, Ravi Vij, Mark A. Schroeder, Rizwan Romee   +5 more
openalex   +1 more source

Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration. [PDF]

, 2014
Adult mammalian epidermis contains multiple stem cell populations in which quiescent and more proliferative stem and progenitor populations coexist. However, the precise interrelation of these populations in homeostasis remains unclear.
Driskell, Iwona, Frye, Michaela, Humphreys, Peter, Oeztuerk-Winder, Feride   +3 more
core   +2 more sources

Stem cells in adult tissues

Seminars in Cell & Developmental Biology, 2002
In recent years the concept of a stem cell has evolved to encompass the hypotheses that stem cells exist within many adult tissues, and that a common 'interchangeable' progenitor cell may exist within the bone marrow capable of regenerating and repairing tissues throughout the body. As more knowledge is gained about stem cells, their potential roles in
BD Technologies, Biotherapy Division Davis Drive, Research Triangle Park, NC 27709, USA ( host institution ), Presnell, Sharon C ( author ), Petersen, Bryon ( author ), Heidaran, Mohammad ( author )   +3 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Human Adipose Stem Cells: From Bench to Bed-Side [PDF]

, 2015
Stem cell-based therapies for repair and regeneration of different tissues are becoming more important in the treatment of several diseases. Adult stem cells currently symbolize the most available source of cell progenitors for tissue engineering and ...
D'ANDREA, FRANCESCO, De Francesco F., Ferraro G., Nicoletti GF, Ricci G.   +4 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Therapeutic effects of hypoimmunogenic universal human iPSC-derived endothelial cells in a humanized mouse model of peripheral artery disease

Stem Cell Research & Therapy
Background Peripheral arterial disease (PAD) is a leading cause of limb disability due to ischemia caused by atherosclerotic plaques. Cell-based therapies using endothelial cells (ECs) have shown promise in promoting angiogenesis for PAD, but challenges ...
Jungju Choi, Nam Gyo Kim, Dasom Kong, Min-Ji Kim, Byeong-Cheol Kang, Daekee Kwon, Da-Hyun Kim, Kyung-Sun Kang   +7 more
doaj   +1 more source

MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu

Frontiers in Immunology, 2018
Human adult stem cells, including umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), have recently been considered a promising alternative treatment for inflammatory bowel disease (IBD) due to their unique immunomodulatory properties and ...
Byung-Chul Lee, Byung-Chul Lee, Nari Shin, Nari Shin, Jin Young Lee, Jin Young Lee, Insung Kang, Insung Kang, Jae-Jun Kim, Jae-Jun Kim, Seung Eun Lee, Seung Eun Lee, Soon Won Choi, Soon Won Choi, Gill A. Webster, Kyung-Sun Kang, Kyung-Sun Kang   +16 more
doaj   +1 more source