Results 141 to 150 of about 797,049 (362)
DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]
, 2020 Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni +5 more
core
Loss of stem cell regenerative capacity within aged niches. [PDF]
, 2007 This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both embryonic and adult stem cells.
Carlson, Morgan, CONBOY, Irina M
core +3 more sources
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Adult-Derived Stem Cells from the Liver Become Myocytes in the Heart in Vivo [PDF]
, 2001 Nadia N. Malouf +6 more
openalex +3 more sources
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System [PDF]
, 1999 Clas B. Johansson +5 more
openalex +1 more source
Potensi Terapi Sel Punca Dalam Dunia Kedokteran Dan Permasalahannya [PDF]
, 2008 Stem cell has become a main focus for not only reseacrhers but also society due to its potency in cell-based therapy. Regardless ethical issues surrounding the human embryonic stem cell, adult human stem cell became the alternative of choice for ...
Aini, N. (Nurul) +4 more
core
, 2004 This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer.
A. T. Natarajan +4 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Stem Cell Research & TherapyBackground Peripheral arterial disease (PAD) is a leading cause of limb disability due to ischemia caused by atherosclerotic plaques. Cell-based therapies using endothelial cells (ECs) have shown promise in promoting angiogenesis for PAD, but challenges ...
Jungju Choi +7 more
doaj +1 more source
Stem Cell Activation in Adult Organisms [PDF]
International Journal of Molecular Sciences, 2016 Stem cells are responsible for the organ and tissue development, growth and maintenance from embryonic stage up to late adult life.[...]
openaire +3 more sources