Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction [PDF]
, 2018 Peter W. Nagle +10 more
openalex +1 more source
Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations. [PDF]
STAR Protoc, 2023 Triolo M, Wade S, Baker N, Khacho M.
europepmc +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Imp interacts with Lin28 to regulate adult stem cell proliferation in the Drosophila intestine. [PDF]
PLoS Genet, 2022 Sreejith P, Malik S, Kim C, Biteau B.
europepmc +1 more source
Effects of Mesenchymal Stem Cells Derived Microvesicles Therapy on Pancreas in Experimentally–Induced Diabetes in Adult Male Albino Rats [PDF]
Mohammad Soliman +3 more
openalex +1 more source
The potential role of adult stem cells in the management of the rheumatic diseases [PDF]
, 2017 Tiziana Franceschetti, Cosimo De Bari
openalex +1 more source
Prmt5 is a regulator of muscle stem cell expansion in adult mice. [PDF]
, 2015 Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling the fate of MuSC is missing.
Braun, Thomas +7 more
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