Matrix: a complex amalgam of structures and functions in tumor microenvironment
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis+3 more
wiley +1 more source
DNA Damage-Induced Inflammatory Microenvironment and Adult Stem Cell Response. [PDF]
Cinat D, Coppes RP, Barazzuol L.
europepmc +1 more source
Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang+6 more
wiley +1 more source
Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage. [PDF]
Berry CW+7 more
europepmc +1 more source
Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei
Megan Munsie+5 more
openalex +1 more source
Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture [PDF]
James L. Sherley
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Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu+9 more
wiley +1 more source
GSK3β, a Master Kinase in the Regulation of Adult Stem Cell Behavior. [PDF]
Racaud-Sultan C, Vergnolle N.
europepmc +1 more source
Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation [PDF]
Norihiro Awaya+3 more
openalex +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source