Results 21 to 30 of about 407,994 (322)
Human iNSC-derived brain organoid model of lysosomal storage disorder in Niemann–Pick disease type C
Cell Death and Disease, 2020 Recent studies on developing three-dimensional (3D) brain organoids from stem cells have allowed the generation of in vitro models of neural disease and have enabled the screening of drugs because these organoids mimic the complexity of neural tissue ...
Seung-Eun Lee +6 more
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Stem Cell Research & Therapy, 2021 Background Human mesenchymal stem cells (hMSCs) therapy has recently been considered a promising treatment for atopic dermatitis (AD) due to their immunomodulation and tissue regeneration ability.
Nari Shin +9 more
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Adult stem cell plasticity [PDF]
The Journal of Pathology, 2002 AbstractObservations made in the last few years support the existence of pathways, in adult humans and rodents, that allow adult stem cells to be surprisingly flexible in their differentiation repertoires. Termed plasticity, this property allows adult stem cells, assumed, until now, to be committed to generating a fixed range of progeny, to switch ...
Nicholas A. Wright +5 more
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Experimental and Molecular Medicine, 2018 Inherited metabolic disease: Restoring motor function by reducing cholesterol An acid secreted by stem cells can reduce the excess cholesterol caused by a genetic metabolic disorder.
Insung Kang +10 more
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Pattern Detection on Glioblastoma's Waddington landscape via Generative Adversarial Networks [PDF]
Cybernetics and Systems (2021), 2021 Glioblastoma (GBM) is a highly morbid and lethal disease with poor prognosis. Their emergent properties such as cellular heterogeneity, therapy resistance, and self-renewal are largely attributed to the interactions between a subset of their population known as glioblastoma-derived stem cells (GSCs) and their microenvironment.
arxiv +1 more source
Cellular Therapy for Repair of Cardiac Damage after Acute Myocardial Infarction
International Journal of Cell Biology, 2009 Cardiovascular diseases, particularly acute myocardial infarction, are the leading causes of death worldwide. Important advances have been made in the secondary treatment for cardiovascular diseases such as heart transplantation and medical and surgical ...
Matthew M. Cook +3 more
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Dynamics of cell-type transition mediated by epigenetic modifications [PDF]
arXiv, 2023 Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells follow attractors of the probability landscape to develop into distinct cell types.
arxiv
An interplay of migratory and division forces as a generic mechanism for stem cell patterns [PDF]
Physical Review E 93, 022405 (2016), 2015 In many adult tissues, stem cells and differentiated cells are not homogeneously distributed : stem cells are arranged in periodic "niches", and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which ...
arxiv +1 more source
Cell Death Discovery, 2023 A correlation between COVID-19 and Alzheimer’s disease (AD) has been proposed recently. Although the number of case reports on neuroinflammation in COVID-19 patients has increased, studies of SARS-CoV-2 neurotrophic pathology using brain organoids have ...
Dasom Kong +8 more
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Definitions for adult stem cells debated [PDF]
Nature, 2018 Sí
Muñoz-Cánoves, Pura, Huch, Meritxell
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