Results 31 to 40 of about 820,702 (356)
Zika virus infection accelerates Alzheimer’s disease phenotypes in brain organoids
Cell Death Discovery, 2022 Alzheimer’s disease (AD) is one of the progressive neurodegenerative diseases characterized by β-amyloid (Aβ) production and Phosphorylated-Tau (p-Tau) protein in the cerebral cortex. The precise mechanisms of the cause, responsible for disease pathology
Seung-Eun Lee +9 more
doaj +1 more source
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body [PDF]
, 2017 Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade.
Annese, Valentina +3 more
core +2 more sources
SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes [PDF]
, 2013 The spermatogenic lineage is established after birth when gonocytes migrate to the basement membrane of seminiferous tubules and give rise to spermatogonial stem cells (SSC). In adults, SSCs reside within the population of undifferentiated spermatogonia (
A Buageaw +48 more
core +8 more sources
Human iNSC-derived brain organoid model of lysosomal storage disorder in Niemann–Pick disease type C
Cell Death and Disease, 2020 Recent studies on developing three-dimensional (3D) brain organoids from stem cells have allowed the generation of in vitro models of neural disease and have enabled the screening of drugs because these organoids mimic the complexity of neural tissue ...
Seung-Eun Lee +6 more
doaj +1 more source
Experimental and Molecular Medicine, 2018 Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging.
Jin Young Lee +9 more
doaj +1 more source
Experimental Hematology & Oncology, 2017 Background Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have
Mauricio Sarmiento Maldonado +7 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Human mesenchymal stem cells (hMSCs) therapy has recently been considered a promising treatment for atopic dermatitis (AD) due to their immunomodulation and tissue regeneration ability.
Nari Shin +9 more
doaj +1 more source
Experimental and Molecular Medicine, 2018 Inherited metabolic disease: Restoring motor function by reducing cholesterol An acid secreted by stem cells can reduce the excess cholesterol caused by a genetic metabolic disorder.
Insung Kang +10 more
doaj +1 more source
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources
Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]
, 2015 Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey +2 more
core +1 more source