Results 41 to 50 of about 407,994 (322)
Heterogeneity of Embryonic and Adult Stem Cells [PDF]
Cell Stem Cell, 2008 New studies suggest that stem cells of embryonic, neural, and hematopoietic origin are heterogeneous, with cells moving between two or more metastable states. These cell states show a bias in their differentiation potential and correlate with specific patterns of transcription factor expression and chromatin modifications.
Thomas Graf, Matthias Stadtfeld
openaire +3 more sources
The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation [PDF]
Bernoulli 2016, Vol. 22, No. 4, 2113-2142, 2014 We generalize the SiZer of Chaudhuri and Marron (J. Amer. Statist. Assoc. 94 (1999) 807-823, Ann. Statist. 28 (2000) 408-428) for the detection of shape parameters of densities on the real line to the case of circular data. It turns out that only the wrapped Gaussian kernel gives a symmetric, strongly Lipschitz semi-group satisfying "circular ...
arxiv +1 more source
Adult Stem and Progenitor Cells
, 2009 The discovery of adult stem cells in most adult tissues is the basis of a number of clinical studies that are carried out, with therapeutic use of hematopoietic stem cells as a prime example. Intense scientific debate is still ongoing as to whether adult stem cells may have a greater plasticity than previously thought. Although cells with some features
Geraerts, Martine, Verfaillie, Catherine
openaire +4 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Stem Cells InternationalConclusions: Weight loss improved donors’ metabolic health and partially recovered ASCs’ anti-inflammatory gene expression and cytokine secretion profiles in monocultures.
Amna Adnan +7 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections result in the temporary loss of smell and taste in about one third of confirmed cases.
Lynn Vitale-Cross +4 more
doaj
Nature Communications, 2023 Bioengineered livers using decellularized scaffolds have been considered as an alternative to donor organs. Here, the authors modulate biophysical properties of decellularized scaffolds by crosslinking with nano-graphene oxide, thereby greatly enhancing ...
Da-Hyun Kim +7 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Perspectives for Clinical Translation of Adipose Stromal/Stem Cells
Stem Cells International, 2019 Adipose stromal/stem cells (ASCs) are an ideal cell type for regenerative medicine applications, as they can easily be harvested from adipose tissue in large quantities.
Mimmi Patrikoski +2 more
doaj +1 more source
Turkish Journal of Hematology, 2014 Cultured human bone marrow mesenchymal cells (MSCs) have immunomodulatory and tissue regenerative properties. This report summarizes the result of post-transplant treatment with MSCs of a 26-year-old patient with aplastic anemia complicated by invasive ...
Hakan Özdoğu +3 more
doaj +1 more source