Results 51 to 60 of about 407,994 (322)
Down-regulation of rpl15 gene expression inhibits development of early hematopoiesis in zebrafish
Di-san junyi daxue xuebao, 2021 Objective To investigate the effect of down-regulation of ribosomal protein l15 (rpl15) gene on early hematopoietic development in zebrafish. Methods The rpl15 morphilino antisense oligo (MO) was designed and synthesized to down-regulate the expression ...
ZHOU Weijun +8 more
doaj +1 more source
Adult gastric stem cells and their niches [PDF]
WIREs Developmental Biology, 2017 Adult gastric stem cells replenish the gastric epithelium throughout life. Recent studies have identified diverse populations of stem cells, progenitor cells, and even differentiated cells that can regain stem cell capacity, so highlighting an unexpected plasticity within the gastric epithelium, both in the corpus and antrum.
Bartfeld, Sina, Koo, Bon-Kyoung
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Transcriptional profiling reveals fundamental differences in iPS-derived progenitors of endothelial cells (PECs) versus adult circulating EPCs [PDF]
arXiv, 2020 There are a number of different stem cell sources that have the potential to be used as therapeutics in vascular degenerative diseases. On the one hand, there are so called endothelial progenitor cells (EPCs), which are typically derived from adult blood. They carry the marker CD34, but the true nature and definition of EPCs is still controversial.
arxiv
Symmetric vs asymmetric stem cell divisions: an adaptation against cancer? [PDF]
, 2013 Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis.
arxiv +1 more source
Unexpected Potential of Adult Stem Cells [PDF]
Annals of the New York Academy of Sciences, 2003 We have identified a population of primitive cells in normal human (h) as well as murine (m) and rat (r), postnatal bone marrow (BM) that have, at the single cell level, multipotent differentiation and extensive proliferation potential, which we named Multipotent Adult Progenitor Cell or MAPC. MAPC differentiate in vitro into most mesodermal cell types
Verfaillie, Catherine +3 more
openaire +4 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation
Frontiers in Cell and Developmental Biology, 2021 Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and ...
Fabián Montecino +6 more
doaj +1 more source
A quantitative system for discriminating induced pluripotent stem cells, embryonic stem cells and somatic cells [PDF]
, 2012 Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines. However, an efficient system to discriminate the cell lines is lacking.
arxiv +1 more source
Seminars in Cell & Developmental Biology, 2002 In recent years the concept of a stem cell has evolved to encompass the hypotheses that stem cells exist within many adult tissues, and that a common 'interchangeable' progenitor cell may exist within the bone marrow capable of regenerating and repairing tissues throughout the body. As more knowledge is gained about stem cells, their potential roles in
BD Technologies, Biotherapy Division Davis Drive, Research Triangle Park, NC 27709, USA ( host institution ) +3 more
openaire +4 more sources