Results 61 to 70 of about 751,739 (361)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Nature Communications, 2023 Bioengineered livers using decellularized scaffolds have been considered as an alternative to donor organs. Here, the authors modulate biophysical properties of decellularized scaffolds by crosslinking with nano-graphene oxide, thereby greatly enhancing ...
Da-Hyun Kim +7 more
doaj +1 more source
Human stem cells and articular cartilage regeneration. [PDF]
, 2012 The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells ...
Inui, Atsuyuki +2 more
core +4 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Turkish Journal of Hematology, 2014 Cultured human bone marrow mesenchymal cells (MSCs) have immunomodulatory and tissue regenerative properties. This report summarizes the result of post-transplant treatment with MSCs of a 26-year-old patient with aplastic anemia complicated by invasive ...
Hakan Özdoğu +3 more
doaj +1 more source
Down-regulation of rpl15 gene expression inhibits development of early hematopoiesis in zebrafish
Di-san junyi daxue xuebao, 2021 Objective To investigate the effect of down-regulation of ribosomal protein l15 (rpl15) gene on early hematopoietic development in zebrafish. Methods The rpl15 morphilino antisense oligo (MO) was designed and synthesized to down-regulate the expression ...
ZHOU Weijun +8 more
doaj +1 more source
Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. [PDF]
, 2017 Implanted biomaterials and biomedical devices generally induce foreign body reaction and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix.
Chu, Julia +9 more
core +2 more sources
Seminars in Cell & Developmental Biology, 2002 In recent years the concept of a stem cell has evolved to encompass the hypotheses that stem cells exist within many adult tissues, and that a common 'interchangeable' progenitor cell may exist within the bone marrow capable of regenerating and repairing tissues throughout the body. As more knowledge is gained about stem cells, their potential roles in
BD Technologies, Biotherapy Division Davis Drive, Research Triangle Park, NC 27709, USA ( host institution ) +3 more
openaire +4 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Perspectives for Clinical Translation of Adipose Stromal/Stem Cells
Stem Cells International, 2019 Adipose stromal/stem cells (ASCs) are an ideal cell type for regenerative medicine applications, as they can easily be harvested from adipose tissue in large quantities.
Mimmi Patrikoski +2 more
doaj +1 more source