Results 81 to 90 of about 820,702 (356)

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

POLYRADICULOPATHY FOLLOWING CAR T-CELL THERAPY FOR LYMPHOID MALIGNANCIES, DIAGNOSTIC CHALLENGES: A REPORT OF 3 CASES

Hematology, Transfusion and Cell Therapy
Objective: Neurotoxicity is a serious but incompletely understood complication of CAR T-cell therapy. here we highlight presentation and diagnostic challenges of non-CNS CAR T-cell therapy complication.
Alfadil Haroon, Nawaf Aldawsari, Naeem Chaudhri, Ali Alahmari, Mahmoud Aljurf, Syed O Ahmed, Abdulwahab Albabtain   +6 more
doaj   +1 more source

Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia

Biology Open, 2014
Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of disorders, diagnosed by progressive gait disturbances with muscle weakness and spasticity, for which there are no treatments targeted at the underlying pathophysiology. Mutations
Yongjun Fan, Gautam Wali, Ratneswary Sutharsan, Bernadette Bellette, Denis I. Crane, Carolyn M. Sue, Alan Mackay-Sim   +6 more
doaj   +1 more source

Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types

Cell Communication and Signaling, 2023
Background Neuronal networks receive and deliver information to regulate bodily functions while the vascular network provides oxygen, nutrients, and signaling molecules to tissues.
Lotta Isosaari, Hanna Vuorenpää, Alma Yrjänäinen, Fikret Emre Kapucu, Minna Kelloniemi, Toni-Karri Pakarinen, Susanna Miettinen, Susanna Narkilahti   +7 more
doaj   +1 more source

c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation

Frontiers in Cell and Developmental Biology, 2021
Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and ...
Fabián Montecino, Natalia González, Natasha Blanco, Manuel J. Ramírez, Adrián González-Martín, Alejandra R. Alvarez, Hugo Olguín   +6 more
doaj   +1 more source

Loss of stem cell regenerative capacity within aged niches. [PDF]

, 2007
This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both embryonic and adult stem cells.
Carlson, Morgan, CONBOY, Irina M
core   +3 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source