Results 81 to 90 of about 1,021,356 (297)
Influence of gut microbiome on multiple myeloma: friend or foe?
Journal for ImmunoTherapy of Cancer, 2020 Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, which typically evolves over time from its precursor, monoclonal gammopathy of undetermined significance.
Marcos de Lima +4 more
doaj +1 more source
Nature Communications, 2022 The biological roles of deubiquitinating enzymes (DUBs) in pancreatic ductal adenocarcinoma (PDAC) are not fully explored. Here the authors perform activity based proteomics with a loss of function genetic screen and identify that USP25 promotes PDAC ...
Jessica K. Nelson +18 more
doaj +1 more source
Stem cell aging in adult progeria
Cell Regeneration, 2015 Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research ...
Hoi-Hung Cheung +2 more
openaire +4 more sources
In search of adult renal stem cells [PDF]
Journal of Cellular and Molecular Medicine, 2004 AbstractThe therapeutic potential of adult stem cells in the treatment of chronic degenerative diseases has becoming increasingly evident over the last few years. Significant attention is currently being paid to the development of novel treatments for acute and chronic kidney diseases too.
ANGLANI, FRANCA +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Nature CommunicationsFunctional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary endpoints of ...
Ehsan Malek +9 more
doaj +1 more source
Developmental toxicity of embryonic 1-naphthol exposure in zebrafish
Di-san junyi daxue xuebao, 2019 Objective To investigate the toxic effects of embryonic exposure to 1-naphthol (1-NAP) on zebrafish development and explore the possible mechanism. Methods Fertilized zebrafish eggs were exposed to 1-NAP at the concentrations of 40, 80, 160 and 200 μmol ...
REN Pingping +4 more
doaj +1 more source
Adult stem cells at work: regenerating skeletal muscle
Cellular and Molecular Life Sciences, 2019 Skeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration.
M. Schmidt +4 more
semanticscholar +1 more source
Dietary Regulation of Adult Stem Cells [PDF]
Current Stem Cell Reports, 2017 Dietary intake is a critical regulator of organismal physiology and health. Tissue homeostasis and regeneration are dependent on adult tissue stem cells that self-renew and differentiate into the specialized cell types. As stem cells respond to cues from their environment, dietary signals and nutrients influence tissue biology by altering the function ...
Mana, Miyeko +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source