Results 81 to 90 of about 751,739 (361)

Identification of side population cells in mouse primordial germ cells and prenatal testis [PDF]

, 2011
In mammals, the stem cells of spermatogenesis are derived from an embryonic cell population called primordial germ cells (PGCs). Spermatogonial stem cells displaying the "side population" (SP) phenotype have been identified in the immature and adult ...
De Felici, Massimo, Fera, Stefania, Grisanti, Laura, Lucia Scaldaferri, Maria, Sanchez, Massimo, Stefanini, Mario, Vicini, Elena   +6 more
core   +2 more sources

Stem Cells: Adult

, 2015
This entry focuses on some of the core ethical issues arising from human adult stem cell research. It begins with a brief exploration of the history and science behind adult stem cell research. It then addresses three main ethical concerns about adult stem cell use, namely, the question of whether research on human embryonic stem cells should be ...
openaire   +2 more sources

Adult Stem Cell Responses to Nanostimuli [PDF]

Journal of Functional Biomaterials, 2015
Adult or mesenchymal stem cells (MSCs) have been found in different tissues in the body, residing in stem cell microenvironments called “stem cell niches”. They play different roles but their main activity is to maintain tissue homeostasis and repair throughout the lifetime of an organism.
openaire   +5 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

POLYRADICULOPATHY FOLLOWING CAR T-CELL THERAPY FOR LYMPHOID MALIGNANCIES, DIAGNOSTIC CHALLENGES: A REPORT OF 3 CASES

Hematology, Transfusion and Cell Therapy
Objective: Neurotoxicity is a serious but incompletely understood complication of CAR T-cell therapy. here we highlight presentation and diagnostic challenges of non-CNS CAR T-cell therapy complication.
Alfadil Haroon, Nawaf Aldawsari, Naeem Chaudhri, Ali Alahmari, Mahmoud Aljurf, Syed O Ahmed, Abdulwahab Albabtain   +6 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]

, 2016
Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa, Bonfanti, Paola, Heimberg, Harry, Heremans, Yves, Leuckx, Gunter, Marazzi, Giovanna, Sassoon, David, Sojoodi, Mozhdeh, Staels, Willem, Stradiot, Leslie, Tanaka, Karo, Van de Casteele, Mark   +11 more
core   +3 more sources

Stem cell aging in adult progeria

Cell Regeneration, 2015
Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research ...
Hoi-Hung Cheung, Duanqing Pei, Wai-Yee Chan   +2 more
openaire   +4 more sources

In search of adult renal stem cells [PDF]

Journal of Cellular and Molecular Medicine, 2004
AbstractThe therapeutic potential of adult stem cells in the treatment of chronic degenerative diseases has becoming increasingly evident over the last few years. Significant attention is currently being paid to the development of novel treatments for acute and chronic kidney diseases too.
ANGLANI, FRANCA, FORINO M, DEL PRETE, DORELLA, TOSETTO, ENRICA, TORREGROSSA R., D'ANGELO, ANGELA   +5 more
openaire   +4 more sources