Results 51 to 60 of about 1,914,795 (248)

Adult pneumococcal vaccination in Northeast Nigeria: Insights into physicians’ knowledge, attitudes, and clinical practices [PDF]

Introduction: Streptococcus pneumoniae is a major cause of lower respiratory tract infections, invasive pneumococcal diseases (IPDs), and rising antibiotic resistance.
Kabiru Idris, Imrana Alhassan Bojude, Dalhat Ibrahim Sulaiman, Adamu Ali Bukar, Umar Mohammed Hassan, Abdulwahab Aliyu, Ibrahim Adamu   +6 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

IAPSM’s Position Paper on Pneumococcal Vaccine (PCV) for Adult Immunization in India

Indian Journal of Community Medicine
Pneumococcal infection among adults is associated with invasive disease and poor outcomes. Pneumococcal vaccine (PCV) introduction has significantly reduced disease burden, invasive disease and reduced the rates of antimicrobial resistance.
Chythra R. Rao, Veena G. Kamath, Anuradha Nadda, Swayam P. Parida, Nikita Sharma, Kapil Goel, Ranjitha S. Shetty, Madhur Verma, Arvind Kumar Singh, Abhisek Mishra, Swosti Kiran, Lalit Sankhe, Madhu Gupta   +12 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Immunofitness in the elderly: The role of vaccination in promoting healthy aging

Human Vaccines & Immunotherapeutics
Aging reshapes immunity through immunosenescence and inflammaging, increasing susceptibility to infection, exacerbating chronic conditions, and blunting vaccine responses.
José Gomez Rial, Esther Redondo, Irene Rivero-Calle, Enrique Mascarós, Daniel Ocaña, Isabel Jimeno, Ángel Gil, Manuel Linares, María Ángeles Onieva-García, Fernando González-Romo, José Yuste, Federico Martinón-Torres   +11 more
doaj   +1 more source

The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

, 2006
Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this.
Msiska, GK, Bennett, Andrea A., Fine, Paul E.M., de Lara, CM, Weir, Rosemary E., Ben-Smith, A, Msiska, Glyn K., Bennett, AR, Crampin, Amelia C, Beverley, Peter C.L., Fine, PE, Gorak-Stolinska, Patricia, Weir, RE, Bennett, Andrea R, Fine, Paul EM, Crampin, Amelia C., Ben-Smith, Anne, Lalor, MK, Dockrell, Hazel M., Floyd, Sian, Msiska, Glyn K, Beverley, Peter, de Lara, Catherine M, Beverley, Peter CL, Lalor, Maeve K., Makamo, K, Weir, Rosemary E, Crampin, AC, Gorak-Stolinska, P, Dockrell, HM, Beverley, PC, Lalor, Maeve K, Dockrell, Hazel M, de Lara, Catherine M., Makamo, Kandakuone, Floyd, S   +35 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Determinants of vaccine hesitancy among primary healthcare workers in Türkiye

Human Vaccines & Immunotherapeutics
Healthcare workers (HCWs) are pivotal to sustaining public confidence in vaccination. This study assessed attitudes toward vaccine hesitancy, vaccine-related knowledge, and professional factors among primary healthcare workers (PHCWs) in Türkiye.
Esra Daharlı
doaj   +1 more source