Results 111 to 120 of about 1,272,279 (406)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Toward an Understanding of Advance Care Planning in Children With Medical Complexity

Pediatrics, 2020
CMC have life-limiting conditions; however, little is known about the experiences of ACP with this group of children. BACKGROUND AND OBJECTIVES: Children with medical complexity (CMC) often have multiple life-limiting conditions with no unifying ...
J. Orkin, L. Beaune, Clara Moore, N. Weiser, Danielle Arje, A. Rapoport, Kathy Netten, S. Adams, E. Cohen, R. Amin   +9 more
semanticscholar   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

Content analysis of Advance Directives completed by patients with advanced cancer as part of an Advance Care Planning intervention : insights gained from the ACTION trial [PDF]

, 2020
Purpose Writing an Advance Directive (AD) is often seen as a part of Advance Care Planning (ACP). ADs may include specific preferences regarding future care and treatment and information that provides a context for healthcare professionals and relatives ...
Caswell, G, Deliens, Luc, Ingravallo, F, Jabbarian, LJ, Johnsen, AT, Kars, MC, Korfage, IJ, Mimić, A, Møller Arnfeldt, C, Preston, NJ, van Delden, JJM, Zwakman, Marieke   +11 more
core   +2 more sources

Educating Healthcare Employees about Advance Care Planning

Asia-Pacific Journal of Oncology Nursing, 2019
The objective of this descriptive article is to provide a background of current research and data on advance care planning. Additionally, a proposed and detailed education initiative for increasing completion and understanding of advance care planning ...
Catherine A Glennon, Wendy Thomas, Katherine Black, Madison Herrig, Jane Ishikawa, Isabel Reedy   +5 more
doaj   +1 more source

Semi‐automated hippocampal avoidance whole‐brain radiotherapy planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Hippocampal avoidance whole‐brain radiotherapy (HA‐WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time‐consuming and may vary in quality, necessitating the development of automated approaches to streamline ...
Dong Joo Rhee, Subha Perni, Kelly J. Perrin, Kevin E. Casey, Alexandra O. Leone, Callistus M. Nguyen, Laurence E. Court, He Wang, Xin Wang, Eun Young Han   +9 more
wiley   +1 more source

The conversation: developing confidence to provide end of life care in Salford nursing homes [PDF]

, 2011
The study was funded by the Burdett Trust for Nursing and partly by Salford Primary Care Trust. A realistic evaluation design was used to collect data using a range of approaches, from before and after surveys of confidence in delivering end of life care,
Attree, M, Gamal, E, Garbutt, D, Johnson, M, Jones, I   +4 more
core  

Experiences of advance care planning in Parkinson’s disease and atypical Parkinsonian disorders: a mixed methods systematic review [PDF]

, 2020
Background and purpose: Advance care planning allows people to plan for their future care needs and can include medical, psychological and social aspects.
Davies, N, Hatter, L, Nimmons, D, Sampson, E, Schrag, A, Walters, K   +5 more
core  

Use of the PREPARE Tool to Increase Completion Rates of Advance Care Planning Documentation [PDF]

, 2022
Practice Problem: One in three adults aged 55 and older admitted to the hospital lack advance care planning. Patients without advance care planning may not receive treatment that reflects their personal values, wishes, and preferences PICOT: The PICOT ...
Thompson, Janella
core   +1 more source