Results 121 to 130 of about 1,403,852 (427)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Intelligent Clinical Documentation: Harnessing Generative AI for Patient-Centric Clinical Note Generation [PDF]

International Journal of Innovative Science and Research Technology: Vol. 9 (2024): No. 5, 994-1008
Comprehensive clinical documentation is crucial for effective healthcare delivery, yet it poses a significant burden on healthcare professionals, leading to burnout, increased medical errors, and compromised patient safety. This paper explores the potential of generative AI (Artificial Intelligence) to streamline the clinical documentation process ...
arxiv   +1 more source

Combining Planning, Reasoning and Reinforcement Learning to solve Industrial Robot Tasks [PDF]

arXiv, 2022
One of today's goals for industrial robot systems is to allow fast and easy provisioning for new tasks. Skill-based systems that use planning and knowledge representation have long been one possible answer to this. However, especially with contact-rich robot tasks that need careful parameter settings, such reasoning techniques can fall short if the ...
arxiv  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Advance care planning for cancer patients: A systematic review of perceptions and experiences of patients, families and healthcare providers [PDF]

, 2015
Background Patients with advanced cancer may benefit from end of life (EOL) planning, but there is evidence that their willingness and desire to engage in advance care planning (ACP) varies. The reasons for this remain poorly understood.
Almack, Auriemma, Barakat, Barnes, Barnes, Boyd, Brinkman-Stoppelenburg, Bv, Carrion, Cherlin, Cox, Danis, De Vleminck, Dow, Duckworth, Díaz-Montes, El-Sahwi, Eliott, Fried, Fu, Horne, Horne, Houttekier, Hu, Hwang, Jezewski, Jezewski, Johnstone, Jones, Keating, Kiely, Laidsaar-Powell, Lamont, Landis, Laryionava, Loberiza, MacDonald, Mackenzie, McKinley, Miccinesi, Michael, Michael, Peppercorn, Robinson, Robinson, Romer, Sahm, Samara, Scott, Seal, Sherwin, Stearns, The SUPPORT Principal Investigators, Thomas, Tieman, Vogel, Walczak, Walling, Zhou   +58 more
core   +1 more source

Toward an Understanding of Advance Care Planning in Children With Medical Complexity

Pediatrics, 2020
CMC have life-limiting conditions; however, little is known about the experiences of ACP with this group of children. BACKGROUND AND OBJECTIVES: Children with medical complexity (CMC) often have multiple life-limiting conditions with no unifying ...
J. Orkin, L. Beaune, Clara Moore, N. Weiser, Danielle Arje, A. Rapoport, Kathy Netten, S. Adams, E. Cohen, R. Amin   +9 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Length of Stay prediction for Hospital Management using Domain Adaptation [PDF]

arXiv, 2023
Inpatient length of stay (LoS) is an important managerial metric which if known in advance can be used to efficiently plan admissions, allocate resources and improve care. Using historical patient data and machine learning techniques, LoS prediction models can be developed.
arxiv  

End of life care: The experiences of advance care planning amongst family caregivers of people with advanced dementia - A qualitative study [PDF]

, 2014
Background: End of life decisions for people with advanced dementia are reported as often being difficult for families as they attempt to make appropriate and justified decisions.
Addicott R., Barbara Jack, Bernard H. R., Bob McClelland, Brenda Roe, Caron C. D., Cresswell J. W., Department of Health, Department of Health, Department of Health, Gott M., Joffe H., Kumar C. T. S., Lawton J., Lincoln Y. S., Lindstrom K. B., National Audit Office, Patton M. Q., Phillips J., Polit D. F., Poppe M., Royal College of Physicians (RCP), Sampson E. L., Silverman D., Silverman D., Susan Elizabeth Ashton, World Health Organisation, World Health Organisation, Yin R. K.   +28 more
core   +1 more source

Measuring Advance Care Planning: Optimizing the Advance Care Planning Engagement Survey [PDF]

Journal of Pain and Symptom Management, 2017
A validated 82-item Advance Care Planning (ACP) Engagement Survey measures a broad range of behaviors. However, concise surveys are needed.The objective of this study was to validate shorter versions of the survey.The survey included 57 process (e.g., readiness) and 25 action items (e.g., discussions).
Deborah E. Barnes, Konrad Fassbender, Michelle Howard, John Boscardin, Carole A. Robinson, Daren K. Heyland, John J. You, Rebecca L. Sudore, Rebecca L. Sudore   +8 more
openaire   +4 more sources