Results 81 to 90 of about 1,272,279 (406)

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Improving Advance Directive Use Through Provider Education at Newtown Primary Care [PDF]

, 2018
Nationally, there seems to be a discrepancy between a patient\u27s desire to talk about end-of-life care and their act of doing so. An advance directive is a legal document that enables an individual facilitate an end-of-life care discussion with someone.
Wong, Timothy
core   +1 more source

Developing a service for patients with very severe chronic obstructive pulmonary disease (COPD) within resources [PDF]

, 2013
Chronic obstructive pulmonary disease (COPD) is a common life-limiting illness with significant burden for patient and carer. Despite this, access to supportive and specialist palliative care is inconsistent and implementation of published good practice ...
Ainscough, Rachel, Boland, Jason, Mahdi, Hazim, Owen, Janet   +3 more
core   +1 more source

Advance care planning in COPD [PDF]

Respirology, 2011
ABSTRACTThe review aims to discuss current concepts in advance care planning (ACP) for patients with COPD, and to provide a narrative review of recent trends in ACP and end‐of‐life care for patients with COPD. ACP, which involves patient–clinician communication about end‐of‐life care, can improve outcomes for patients and their families, and may be ...
Kevin R. Patel, Daisy J.A. Janssen, J. Randall Curtis   +2 more
openaire   +3 more sources

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, Volume 19, Issue 7, Page 2014-2037, July 2025.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The role of acculturation in the process of advance care planning among Chinese immigrants:A narrative systematic review [PDF]

, 2023
Background: Acculturation is the process of two different cultures coming into contact. It is unclear how acculturation influences Chinese immigrants’ engagement in advance care planning due to the complexity and multifaceted nature of both acculturation
Heide, Agnes van der, Korfage, Ida J., Martina, Diah, Rietjens, Judith A.C., Zhu, Tingting   +4 more
core   +1 more source

Hope and advance care planning in advanced cancer: Is there a relationship?

Cancer, 2021
Clinicians often cite a fear of giving up hope as a reason they defer advance care planning (ACP) among patients with advanced cancer. The objective of this study was to determine whether engagement in ACP affects hope in these patients.
Michael G Cohen, A. Althouse, R. Arnold, H. Bulls, D. White, E. Chu, M. Rosenzweig, Kenneth J. Smith, Yael Schenker   +8 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

How do general practitioners conceptualise advance care planning in their practice? : a qualitative study [PDF]

, 2016
Objectives : To explore how GPs conceptualise advance care planning (ACP), based on their experiences with ACP in their practice. Methods : Five focus groups were held with 36 GPs. Discussions were analysed using a constant comparative method. Results :
Beernaert, Kim, De Vleminck, Aline, Deliens, Luc, Houttekier, Dirk, Pardon, Koen, Vander Stichele, Robert   +5 more
core   +2 more sources