Results 191 to 200 of about 849,640 (304)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Seeking consensus on dilemmas related to euthanasia in dementia based on an advance directive: a Delphi study from a medical, ethical and legal perspective. [PDF]

J Med Ethics
de Boer ME, Coers DO, Sizoo EM, Ten Bokkel Huinink DMJ, Leget CJW, Hertogh CMPM, DALT project group.   +6 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

New VSED Advance Directive: Improved Documentation to Avoid Late-Stage Dementia. [PDF]

J Law Med Ethics
Pope TM, Brodoff LE, Glass EM, Menzel PT, Miller RM.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Timing Prompts for Advance Care Planning Discussions and Advance Directive Completion.

JAMA Netw Open
Wenger NS, Sanz Vidorreta FJ, Tseng CH, Gonzalez V, Hays RD, Rahimi M, Gibbs L, Santos K, Sudore RL, Walling AM.   +9 more
europepmc   +1 more source

Knowledge, Attitudes, and Practices of Healthcare Providers Towards Advance Directive for COPD Patients in Riyadh, Saudi Arabia. [PDF]

Healthcare (Basel)
Qutob RA, Alaryni A, Alammari Y, Almaimani MK, Alghamdi A, Alotay AA, Alhajery MA, Faqihi FA, Daghistani Y, AlHussaini KI, Aldeghaither S, Alamri A, Alsharif B, Alshamrani H, Mubarak E.   +14 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Role of Uncertainty in Illness and Coping Strategies in Advance Directive Completion in Patients With End-stage Liver Disease. [PDF]

J Clin Gastroenterol
Fuson O, Mitra A, Little C, Hiatt S, Franklin H, Dieckmann NF, Hansen L.   +6 more
europepmc   +1 more source