Results 91 to 100 of about 1,191,211 (370)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Advance Directives and End-of-Life Care: Completion, Conversations, and Concerns of Burlington Housing Authority Residents [PDF]

open access: yes, 2011
Introduction: •An Advance Directive is a document that allows patients to declare their wishes regarding medical care and decision making should they become unable to communicate their preferences due to an accident or illness.
Clark, Katherine   +9 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Ridding Ourselves of Noxious “Death Panel” Discourse

open access: yesVoices in Bioethics, 2014
On Friday, April 11, 2014, Senator Tom Coburn (R-OK), along with co-sponsors Senators Chris Coons (D-DE) and Richard Blumenthal (D-CT), introduced the “Medicare Choices Empowerment and Protection Act" (S.
Lillian Ringel
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Nurses' knowledge of advance directives and perceived confidence in end‐of‐life care: a cross‐sectional study in five countries

open access: yesInternational Journal of Nursing Practice, 2016
Nurses' knowledge regarding advance directives may affect their administration and completion in end‐of‐life care. Confidence among nurses is a barrier to the provision of quality end‐of‐life care.
RN MichalItzhaki
semanticscholar   +1 more source

A study on the relationship of death anxiety and the completion of advance directives for oncology social workers [PDF]

open access: yes
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Peck, Marlys R., 1964-
core   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Older Adult Opinions of “Advance Driving Directives”

open access: yesJournal of Primary Care & Community Health, 2013
Background: Discussions about driving cessation are difficult. “Advance driving directives” (ADDs), like advance directives for end-of-life care, would allow drivers to designate someone to help make driving decisions for them in the future.
Marian E. Betz   +2 more
doaj   +1 more source

Advance care directives: Citizens, patients, doctors, institutions

open access: yesJournal of Public Health Research, 2019
Italian Law no. 219/2017 established the advance care directives (“Disposizioni anticipate di trattamento” – DAT), a legal document specifying the person’s wishes in relation to health, drawn up in case of the possible future incapacity to make informed ...
Paola Delbon   +2 more
doaj   +1 more source

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