Results 131 to 140 of about 739,788 (312)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
, 1993 In sum, advance directives have been proposed as the answer to the problem of how to empower patients so that they maintain control of their care even when incompetent. We have not yet shown that directives will answer that need. Indeed, the question may
Teno, Joan M., Lynn, Joanne
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Persistent Vegetative State, Prospective Thinking, and Advance Directives
, 2003 This article begins with a discussion of persistent vegetative state (PVS), focusing on concerns related to both diagnosis and prognosis and paying special attention to the 1994 Multi-Society Task Force report on the medical aspects of PVS.
Mappes, Thomas A.
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Direito dos pacientes às diretivas antecipadas de vontade
Revista BioéticaResumo Este estudo investigou o conhecimento que 55 pacientes com doenças terminais tinham sobre seu diagnóstico, prognóstico e a possibilidade de registrar seus desejos no final de vida sob a forma de diretivas antecipadas de vontade.
Maria Aparecida Scottini +2 more
doaj +1 more source
The Importance of Living Wills and Advance Directives
, 2009 Living wills and advance directives are important components of patients' medical records, which all too often do not indicate the appropriate palliative care measures the patient desires.
Heather Alfonso, Alfonso, Heather
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Implementation status quo of advance medical directives
Huli yanjiu, 2019 This article summarized the implementation status quo and legal foundation of the advanced medical directives,analyzed the public′s understanding and the problems faced in the implementation of the advanced medical directives,in order to provide the ...
蒋灵俊, 刘素珍
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source